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Metastron Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Metastron (strontium-89 chloride) Injection is a radiopharmaceutical drug used for the relief of bone pain in patients with painful skeletal metastases (cancer). This medication is available in generic form. Common side effects include chills, fever, flushing, and a mild increase in bone pain 36 to 72 hours after injection.

The recommended dose of Metastron is 148 MBq, 4 mCi, administered by slow intravenous injection (1-2 minutes). Alternatively, a dose of 1.5 - 2.2 MBq/kg, 40-60 μCi/kg body weight may be used. Metastron may interact with other drugs. Tell your doctor all medications and supplements you use. Metastron is not recommended for use during pregnancy. It may harm a fetus. Metastron is not recommended for use while breastfeeding.

Our Metastron (strontium-89 chloride) Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Metastron FDA Prescribing Information: Side Effects
(Adverse Reactions)


A single case of fatal septicemia following leukopenia was reported during clinical trials. Most severe reactions of marrow toxicity can be managed by conventional means.

A small number of patients have reported a transient increase in bone pain at 36 to 72 hours after injection. This is usually mild and self-limiting, and controllable with analgesics. A single patient reported chills and fever 12 hours after injection without long-term sequelae.

Additional postmarketing reactions include the following: hot flush.

Read the entire FDA prescribing information for Metastron (Strontium-89)


Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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