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Methergine

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Methergine

Methergine®
(methylergonovine maleate) Tablets, USP
(methylergonovine maleate) Injection, USP

DRUG DESCRIPTION

Methergine® (methylergonovine maleate) is a semi-synthetic ergot alkaloid used for the prevention and control of postpartum hemorrhage.

Methergine is available in sterile ampuls of 1 mL, containing 0.2 mg methylergonovine maleate for intramuscular or intravenous injection and in tablets for oral ingestion containing 0.2 mg methylergonovine maleate.

Tablets

Active Ingredient: methylergonovine maleate, USP, 0.2 mg.

Inactive Ingredients: acacia, carnauba wax, D&C Red #7, FD&C Blue #1, gelatin special, lactose, maleic acid, mixed parabens, povidone, sodium benzoate, sodium hydroxide, starch, stearic acid, sucrose, talc, and titanium dioxide.

Ampuls: 1 mL, clear, colorless solution.

Active Ingredient: methylergonovine maleate, USP, 0.2 mg.

Inactive Ingredients: maleic acid, 0.10 mg; sodium chloride, 7.0 mg; water for injection, qs to 1 mL.

Chemically, methylergonovine maleate is designated as ergoline-8-carboxamide, 9,10-didehydro-N-[1-(hydroxymethyl)propyl]-6-methyl-, [8β(S)]-, (Z)-2-butenedioate (1:1) (salt).

Its structural formula is

Methergine® (methylergonovine maleate) Structural Formula Illustration

What are the possible side effects of methylergonovine (Methergine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • pain, swelling, warmth, or redness under your skin;
  • seizure (convulsions);
  • feeling like you might pass out;
  • pounding heartbeats or fluttering in your chest;
  • slow heart rate, trouble breathing;
  • blood in your urine;
  • severe weakness, muscle cramps, confusion, slurred speech,...

Read All Potential Side Effects and See Pictures of Methergine »

What are the precautions when taking methylergonovine maleate (Methergine)?

Before taking methylergonovine, tell your doctor or pharmacist if you are allergic to it; or to similar ergot alkaloids (such as ergonovine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, high blood pressure, heart disease (such as venoatrial shunts, mitral valve stenosis, chest pain, recent heart attack), diabetes, high cholesterol, smoking/tobacco use, blood vessel disease (such as Raynaud's disease), complications during pregnancy (such as preeclampsia, eclampsia).

This drug may make you dizzy. Do not drive, use...

Read All Potential Precautions of Methergine »

Last reviewed on RxList: 7/6/2012
This monograph has been modified to include the generic and brand name in many instances.

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Methergine - User Reviews

Methergine User Reviews

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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