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Methergine Side Effects Center
Pharmacy Editor: Melissa Conrad Stöppler, MD
Methergine (methylergonovine) is in a group of drugs called ergot alkaloids. It affects the smooth muscle of a woman's uterus, improving the muscle tone as well as the strength and timing of uterine contractions. It is administered in the postpartum period to help deliver the placenta and to help control bleeding and other uterine problems after childbirth. Side effects can include nausea, vomiting, diarrhea, leg cramps, or dizziness. Other side effects can also occur. Methergine can be given in tablet form, as an intramuscular injection, or intravenously.
Methylergonovine may pass into breast milk in small amounts and could affect a nursing baby. In some cases this drug may be used for up to 1 week after a baby is born. It is important to discuss with your doctor about whether you should breast-feed during that time.
Our Methergine Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Methergine in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- increased blood pressure (severe headache, blurred vision);
- seizure (convulsions);
- feeling light-headed, fainting;
- pounding heartbeat;
- chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; or
Other less serious side effects are more likely to occur, such as:
- nausea, vomiting, diarrhea;
- leg cramps;
- ringing in your ears;
- stuffy nose; or
- unpleasant taste in your mouth.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Methergine (Methylergonovine Maleate) »
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Methergine Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these rare but serious side effects occur: fast/slow heartbeat, shortness of breath, cold hands/feet, pain/redness/swelling of arms or legs.
Seek immediate medical attention if any of these rare but serious side effects occur: chest pain, vision changes, confusion, seizures.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Methergine (Methylergonovine Maleate)»
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Methergine FDA Prescribing Information: Side Effects
The most common adverse reaction is hypertension associated in several cases with seizure and/or headache. Hypotension has also been reported. Abdominal pain (caused by uterine contractions), nausea and vomiting have occurred occasionally. Rarely observed reactions have included: acute myocardial infarction, transient chest pains, vasoconstriction, vasospasm, coronary arterial spasm, bradycardia, tachycardia, dyspnea, hematuria, thrombophlebitis, water intoxication, hallucinations, leg cramps, dizziness, tinnitus, nasal congestion, diarrhea, diaphoresis, palpitation, rash, and foul taste.1
There have been rare isolated reports of anaphylaxis, without a proven causal relationship to the drug product.
The following adverse drug reactions have been derived from post-marketing experience with Methergine via spontaneous case reports. Because these reactions are reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency which is therefore categorized as not known.
Nervous system disorders
Drug Abuse And Dependence
Methergine (methylergonovine maleate) has not been associated with drug abuse or dependence of either a physical or psychological nature.
Read the entire FDA prescribing information for Methergine (Methylergonovine Maleate) »
Additional Methergine Information
Methergine - User Reviews
Methergine User Reviews
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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