August 29, 2016
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Methyclothiazide Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 2/23/2016

Methyclothiazide is a thiazide diuretic/antihypertensive used to treat high blood pressure (hypertension), and is also used as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, corticosteroid and estrogen therapy, and various forms of renal dysfunction such as nephritic syndrome, acute glomerulonephritis, and chronic renal failure. Common side effects of Methyclothiazide include dizziness, lightheadedness, headache, blurred vision, loss of appetite, stomach upset, diarrhea, or constipation as your body adjusts to the medication. Other side effects of Methyclothiazide include decreased sexual ability or increased sensitivity to the sun.

The usual adult dose of Methyclothiazide for hypertension ranges from 2.5 to 5 mg once daily. Methyclothiazide may interact with digitalis, steroids, ACTH, insulin, norepinephrine, tubocurarine, lithium, or other antihypertensive drugs. Tell your doctor all medications and supplements you use. During pregnancy, Methyclothiazide should be used only if prescribed. Thiazides pass into breast milk. Because of the potential for serious adverse reactions in nursing infants, consult your doctor before breastfeeding.

Our Methyclothiazide Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Methyclothiazide FDA Prescribing Information: Side Effects
(Adverse Reactions)


Adverse reactions are usually reversible upon reduction of dosage or discontinuation of methyclothiazide (methyclothiazide (methyclothiazide (methyclothiazide tablet 5 mg) tablet 5 mg) tablet 5 mg) tablets. Whenever adverse reactions are moderate or severe, it may be necessary to discontinue the drug.

The following adverse reactions have been observed, but there has not been enough systematic collection of data to support an estimate of their frequency. Consequently the reactions are categorized by organ system and are listed in decreasing order of severity and not frequency.

Body as a Whole:Headache, cramping, weakness.

Cardiovascular System: Orthostatic hypotension (may be potentiated by alcohol, barbiturates, or narcotics).

Digestive System: Pancreatitis, jaundice (intrahepatic cholestatic), sialadenitis, vomiting, diarrhea, nausea, gastric irritation, constipation, anorexia.

Hemic and Lymphatic System: Aplastic anemia, hemolytic anemia, agranulocytosis, leukopenia, thrombocytopenia.

Hypersensitivity Reactions: Anaphylactic reactions, necrotizing angiitis (vasculitis, cutaneous vasculitis), Stevens-Johnson syndrome, respiratory distress including pneumonitis and pulmonary edema, fever, purpura, urticaria, rash, photosensitivity.

Metabolic and Nutritional Disorders: Hyperglycemia, hyperuricemia, electrolyte imbalance (see PRECAUTIONS section), hypercalcemia.

Nervous System: Vertigo, dizziness, paresthesias, muscle spasm, restlessness.

Special Senses: Transient blurred vision, xanthopsia.

Urogenital System: Glycosuria.

Read the entire FDA prescribing information for Methyclothiazide (Methyclothiazide Tablet 5 mg)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Get tips on handling your hypertension.