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Acute overdosage may produce acute hypotension with other responses attributable to brain and gastrointestinal malfunction (excessive sedation, weakness, bradycardia, dizziness, lightheadedness, constipation, distention, flatus, diarrhea, nausea, vomiting).
In the event of overdosage, symptomatic and supportive measures should be employed. Management includes special attention to cardiac rate and output, blood volume, electrolyte balance, paralytic ileus, urinary function and cerebral activity.
Sympathomimetic drugs [e.g., levarterenol, epinephrine, ARAMINE* (Metaraminol Bitartrate, MSD)] may be indicated.
The acute intravenous LD50 of Methyldopate HCl (methyldopate hydrochloride injection, solution) in the mouse is 321 mg/kg.
Methyldopate hydrochloride is contraindicated in patients:
-with active hepatic disease, such as acute hepatitis and active cirrhosis.
-with liver disorders previously associated with methyldopa therapy (see WARNINGS).
-with hypersensitivity to any component of this product, including sulfites (see WARNINGS).
-on therapy with monoamine oxidase (MAO) inhibitors.
Last reviewed on RxList: 8/11/2008
Additional Methyldopate Hcl Information
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