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Methyldopate Hcl

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Methyldopate Hcl

Methyldopate Hcl

Methyldopate Hcl Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Methyldopate HCl (methyldopate hydrochloride injection, solution) is an antihypertensive drug used in the treatment of hypertensive crises. The brand name of this medication is discontinued, but generic versions may be available. Common side effects include dry mouth, drowsiness, headache, or fluid retention in legs, feet, arms, or hands.

The usual adult dosage of Methyldopate HCl intravenously is 250 mg to 500 mg at six-hour intervals as required. The maximum recommended intravenous dose is 1 gram every six hours. Methyldopate HCl may interact with other antihypertensive drugs, anesthetics, lithium, and monoamine oxidase inhibitors (MAOIs). Tell your doctor all medications and supplements you use. During pregnancy, Methyldopate HCl should be used only if prescribed. This drug passes into breast milk. Use caution if breastfeeding and consult your doctor before breastfeeding.

Our Methyldopate HCl (methyldopate hydrochloride injection, solution) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Methyldopate Hcl FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

Sedation, usually transient, may occur during the initial period of therapy or whenever the dose is increased. Headache, asthenia, or weakness may be noted as early and transient symptoms. However, significant adverse effects due to methyldopa have been infrequent and this agent usually is well tolerated. The following adverse reactions have been reported and, within each category, are listed in order of decreasing severity.

Cardiovascular: Aggravation of angina pectoris, congestive heart failure, prolonged carotid sinus hypersensitivity, paradoxical pressor response with intravenous use, orthostatic hypotension (decrease daily dosage), edema and weight gain, bradycardia.

Digestive: Pancreatitis, colitis, vomiting, diarrhea, sialadenitis, sore or "black" tongue, nausea, constipation, distension, flatus, dryness of mouth.

Endocrine: Hyperprolactinemia.

Hematologic: Bone marrow depression, leukopenia, granulocytopenia, thrombocytopenia, hemolytic anemia; positive tests for antinuclear antibody, LE cells, and rheumatoid factor, positive Coombs tests.

Hepatic: Liver disorders including hepatitis, jaundice, abnormal liver function test (see WARNINGS).

Hypersensitivity: Myocarditis, pericarditis, vasculitis, lupus-like syndrome, drug-related fever, eosinophilia.

Nervous System/Psychiatric: Parkinsonism, Bell's palsy, decreased mental acuity, choreoathetotic movements, symptoms of cerebrovascular insufficiency, psychic disturbances including nightmares and reversible mild psychoses or depression, headache, sedation, asthenia or weakness, dizziness, lightheadedness, paresthesias.

Metabolic: Rise in BUN.

Musculoskeletal: Arthralgia, with or without joint swelling; myalgia.

Respiratory: Nasal stuffiness.

Skin: Toxic epidermal necrolysis, rash.

Urogenital: Amenorrhea, breast enlargement, gynecomastia, lactation, impotence, decreased libido.

Read the entire FDA prescribing information for Methyldopate Hcl (Methyldopate Hydrochloride Injection, Solution) »

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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