August 23, 2016
Recommended Topic Related To:


"Repeated administration of ketamine may help sustain the antidepressant effect in patients with treatment-resistant depression beyond the initial dose, a new study shows.

Ketamine, an injectable anesthetic, has demonstrated a rapid an"...





Acute Toxicity

One case has been recorded in which a 6-year-old girl died after two doses of Metopirone (metyrapone) , 2 g.

Oral LD50 in animals (mg/kg): rats, 521; maximum tolerated intravenous dose in one dog, 300.

Signs and Symptoms

The clinical picture of poisoning with Metopirone (metyrapone) is characterized by gastrointestinal symptoms and by signs of acute adrenocortical insufficiency.

Cardiovascular System: Cardiac arrhythmias, hypotension, dehydration.

Nervous System and Muscles: Anxiety, confusion, weakness, impairment of consciousness.

Gastrointestinal System: Nausea, vomiting, epigastric pain, diarrhea.

Laboratory Findings: Hyponatremia, hypochloremia, hyperkalemia.

Combined Poisoning

In patients under treatment with insulin or oral antidiabetics, the signs and symptoms of acute poisoning with Metopirone (metyrapone) may be aggravated or modified.


There is no specific antidote. Besides general measures to eliminate the drug and reduce its absorption, a large dose of hydrocortisone should be administered at once, together with saline and glucose infusions.

Surveillance: For a few days blood pressure and fluid and electrolyte balance should be monitored.


Metopirone (metyrapone) is contraindicated in patients with adrenal cortical insufficiency, or hypersensitivity to Metopirone (metyrapone) or to any of its excipients.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 12/14/2010


Metopirone - User Reviews

Metopirone User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Metopirone sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Women's Health

Find out what women really need.

Related Drugs
Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations