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Cardiovascular System: Hypotension

Gastrointestinal System: Nausea, vomiting, abdominal discomfort or pain.

Central Nervous System: Headache, dizziness, sedation.

Dermatologic System: Allergic rash.

Hematologic System: Rarely, decreased white blood cell count or bone marrow depression.

Drugs affecting pituitary or adrenocortical function, including all corticosteroid therapy, must be discontinued prior to and during testing with Metopirone (metyrapone) .

The metabolism of Metopirone (metyrapone) is accelerated by phenytoin; therefore, results of the test may be inaccurate in patients taking phenytoin within two weeks before. A subnormal response may occur in patients on estrogen therapy.

Metopirone (metyrapone) inhibits the glucuronidation of acetaminophen and could possibly potentiate acetaminophen toxicity.

Last reviewed on RxList: 12/14/2010
This monograph has been modified to include the generic and brand name in many instances.