MetroGel Vaginal (Metronidazole) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Metrogel Vaginal

Yeast Infection »

What is yeast?

Yeast is a fungus scientifically referred to as Candida. The specific type of fungus most commonly responsible for vaginitis is Candida albicans. Yeast is commonly present on normal human skin and in areas of moisture, such as the mouth and vagina. In fact, it is estimated that between 20%-50% of healthy women normally carry yeast in the vaginal area.

What is vaginitis?

Vaginitis is inflammation of the vagina. Vaginitis is very common and is reported by as many as 75% of women at some point in their lives. Vaginitis can be caused by a number of infections, including bacteria (such as Gardnerella and gonorrhea), protozoans (such as trichomonas), and yeast (Candida). Vaginal yeast infection, which is the most common form of vaginitis, is often referred to as vaginal Candidiasis.

What is vulvitis?

Vulvitis is inflammation of the external ...

Read the Yeast Infection article »

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MetroGel Vaginal

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METROGEL-VAGINAL
(metronidazole) Gel

FOR INTRAVAGINAL USE ONLY
NOT FOR OPHTHALMIC, DERMAL, OR ORAL USE

DRUG DESCRIPTION

METROGEL-VAGINAL (metronidazole) is the intravaginal dosage form of the synthetic antibacterial agent, metronidazole, USP at a concentration of 0.75%. Metronidazole is a member of the imidazole class of antibacterial agents and is classified therapeutically as an antiprotozoal and antibacterial agent. Chemically, metronidazole is a 2-methyl-5-nitroimidazole-1-ethanol. It has a chemical formula of C₆H₉N₃O₃, a molecular weight of 171.16, and has the following structure:

METROGEL-VAGINAL (metronidazole) Structural Formula Illustration

METROGEL-VAGINAL (metronidazole) is a gelled, purified water solution, containing metronidazole at a concentration of 7.5 mg/g (0.75%). The gel is formulated at pH 4.0. The gel also contains carbomer 934P, edetate disodium, methyl paraben, propyl paraben, propylene glycol, and sodium hydroxide.

Each applicator full of 5 grams of vaginal gel contains approximately 37.5 mg of metronidazole.

What are the possible side effects of metronidazole vaginal (MetroGel-Vaginal, Vandazole)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Rare but serious side effects may include:

seizure (convulsions); or
numbness, burning, pain, or tingly feeling in your hands or feet.

Less serious side effects may include:

mild burning or stinging when the medication is applied;
pelvic pain or cramps;
loss...

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What are the precautions when taking metronidazole (MetroGel Vaginal)?

Before using metronidazole, tell your doctor or pharmacist if you are allergic to it; or to other nitroimidazole antibiotics (e.g., tinidazole); or if you have any other allergies. This product may contain inactive ingredients (such as paraben preservatives), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: seizures, liver disease, certain blood disorders (blood dyscrasias), nervous system disease.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages.

This medication should be used only if...

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Last reviewed on RxList: 4/20/2009
This monograph has been modified to include the generic and brand name in many instances.