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Use of dosages of intravenous metronidazole higher than those recommended has been reported. These include the use of 27 mg/kg three times a day for 20 days, and the use of 75 mg/kg as a single loading dose followed by 7.5 mg/kg maintenance doses. No adverse reactions were reported in either of the two cases.
Oral metronidazole has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.
Metronidazole Injection, USP RTU is contraindicated in patients with a prior history of hypersensitivity to metronidazole or other nitroimidazole derivatives.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 6/6/2012
Additional Metronidazole Injection Information
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