Metronidazole Injection (Metronidazole Injection) Patient Information: Side Effects and Drug Images at RxList

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May 27, 2012

Metronidazole Injection

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Metronidazole
(metronidazole (metronidazole (metronidazole injection) injection) ) Injection Sterile

For Intravenous Infusion Only.

WARNING

Metronidazole (metronidazole (metronidazole injection) injection) has been shown to be carcinogenic in mice and rats (see PRECAUTIONS). Its use, therefore, should be reserved for serious anaerobic infections where, in the judgment of the physician, the benefit outweighs the possible risk.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Metronidazole Injection USP and other antibacterial drugs, Metronidazole (metronidazole (metronidazole injection) injection) Injection USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

DRUG DESCRIPTION

Metronidazole (metronidazole (metronidazole injection) injection) Injection USP, sterile, is a parenteral dosage form of a synthetic antibacterial agent, 2-methyl-5-nitroimidazole-1-ethanol:

Metronidazole(metronidazole) Structural Formula Illustration

Each 100 mL of Metronidazole (metronidazole (metronidazole injection) injection) Injection USP contains a sterile, nonpyrogenic, isotonic, buffered solution of Metronidazole (metronidazole (metronidazole injection) injection) USP 500 mg, Sodium Chloride USP 740 mg, Dibasic Sodium Phosphate•7H₂O USP 112 mg, and Citric Acid Anhydrous USP 40 mg in Water for Injection USP. Metronidazole (metronidazole (metronidazole injection) injection) Injection USP has a calculated osmolarity of 297 mOsmol/liter and a pH of 5.8 (4.5–7.0). Sodium content: 13.5 mEq/container.

The PAB®

plastic container system is a copolymer of ethylene and propylene formulated and developed for parenteral drugs. The copolymer contains no plasticizers and exhibits virtually no leachability. The safety of the plastic container has been confirmed by biological evaluation procedures.

The material passes Class VI testing as specified in the U.S. Pharmacopeia for Biological Tests – Plastic Containers. These tests have shown that the container is nontoxic and biologically inert. The container-solution unit is a closed system and is not dependent upon entry of external air during administration. No overwrap is necessary.

Last reviewed on RxList: 6/19/2009
This monograph has been modified to include the generic and brand name in many instances.