"The American Heart Association/American Stroke Association has issued a new scientific statement on the rationale for the inclusion and exclusion criteria for intravenous alteplase (tissue plasminogen activator [tPA]) in acute ischemic stroke."...
(Generic versions may still be available.)
(mexiletine hydrochloride) Capsule
Capsules of 150 mg, 200 mg and 250 mg
MEXITIL® (mexiletine hydrochloride, USP) is an orally active antiarrhythmic agent available as 150 mg, 200 mg and 250 mg capsules. 100 mg of mexiletine hydrochloride is equivalent to 83.31 mg of mexiletine base. It is a white to off-white crystalline powder with slightly bitter taste, freely soluble in water and in alcohol. MEXITIL (mexiletine hcl) has a pKa of 9.2.
Chemically, MEXITIL (mexiletine hcl) is 1-methyl-2-(2, 6-xylyloxy) ethylamine hydrochloride and has the following structural formula:
MEXITIL (mexiletine hcl) capsules contain the following excipients: colloidal silicon dioxide, corn starch, magnesium stearate, titanium dioxide, gelatin, pharmaceutical glaze, simethicone, FD&C Red No. 40, and FD&C Blue No. 1; the MEXITIL (mexiletine hcl) 150 mg and 250 mg capsules also contain FD&C Yellow No. 10 and D&C Red No. 28. MEXITIL (mexiletine hcl) capsules may contain one or more of the following components: sodium lauryl sulfate, lecithin, shellac, and FD&C Blue No. 1 Aluminum Lake.
What are the possible side effects of mexiletine (Mexitil)?
If you experience any of the following serious side effects, stop taking mexiletine and seek emergency medical attention:
- an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
- a new or a worsening irregular heartbeat pattern;
- wheezing, coughing, chest pain, or chest discomfort;
- unusual bruising or bleeding; or
- fever, sore throat, a sore mouth, mouth ulcers, or an infection.
Other, less serious side effects may be more likely to occur. Continue to take mexiletine and talk to...
What are the precautions when taking mexiletine hcl (Mexitil)?
Before taking mexiletine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: other heart problems (such as heart failure, slow heartbeat, previous heart attack), liver problems, seizure disorder.
This drug may make you dizzy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages.
During pregnancy, this medication should be used only when clearly...
Last reviewed on RxList: 4/8/2009
This monograph has been modified to include the generic and brand name in many instances.
Additional Mexitil Information
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