Mexitil (Mexiletine HCl) Drug Information: Overdosage and Contraindications

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May 27, 2012

Mexitil

Arrhythmia »

Introduction to Arrhythmia

An irregular heartbeat is an arrhythmia (also called dysrhythmia). Heart rates can also be irregular. A normal heart rate is 50 to 100 beats per minute. Arrhythmias and abnormal heart rates don't necessarily occur together. Arrhythmias can occur with a normal heart rate, or with heart rates that are slow (called bradyarrhythmias -- less than 50 beats per minute). Arrhythmias can also occur with rapid heart rates (called tachyarrhythmias -- faster than 100 beats per minute). In the United States, more than 850,000 people are hospitalized for an arrhythmia each year.

What causes an arrhythmia?

Arrhythmias may be caused by many different factors, including:

Coronary artery disease.
Electrolyte imbalances in your blood (such as sodium or potassium).
Changes in your heart muscle.
Injury from a heart attack.
Healing process after heart surgery.
Irregula...

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Please Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

OVERDOSE

Clinical findings associated with MEXITIL (mexiletine hydrochloride, USP) overdosage have included drowsiness, confusion, nausea, hypotension, sinus bradycardia, paresthesia, seizures, bundle branch block, AV heart block, asystole, ventricular tachyarrhythmia, including ventricular fibrillation, cardiovascular collapse and coma. The lowest known dose in a fatality case was 4.4g with postmortem serum mexiletine level of 34-37 mcg/ml (Jequier P. et al. Lancet 1976: 1 (7956): 429). Patients have recovered from ingestion of 4g to 18g of mexiletine (Frank S. E. et al. Am J Emerg Med 1991: 9:43-48).

There is no specific antidote for MEXITIL (mexiletine hcl) . Management of MEXITIL (mexiletine hcl) overdosage includes general supportive measures, close observation and monitoring of vital signs. In addition, the use of pharmacologic interventions (e.g., pressor agents, atropine or anticonvulsants) or transvenous cardiac pacing is suggested, depending on the patient's clinical condition.

CONTRAINDICATIONS

MEXITIL (mexiletine hydrochloride, USP) is contraindicated in the presence of cardiogenic shock or pre-existing second- or third-degree AV block (if no pacemaker is present).

Last reviewed on RxList: 4/8/2009
This monograph has been modified to include the generic and brand name in many instances.