Micro-K for Liquid Suspension
(Generic versions may still be available.)
BECAUSE OF REPORTS OF INTESTINAL AND GASTRIC ULCERATION AND BLEEDING WITH CONTROLLED-RELEASE POTASSIUM CHLORIDE PREPARATIONS, THESE DRUGS SHOULD BE RESERVED FOR THOSE PATIENTS WHO CANNOT TOLERATE OR REFUSE TO TAKE IMMEDIATE-RELEASE LIQUIDS/EFFERVESCENT POTASSIUM PREPARATIONS OR FOR PATIENTS IN WHOM THERE IS A PROBLEM OF COMPLIANCE WITH THESE PREPARATIONS.
1. For the treatment of patients with hypokalemia, with or without metabolic alkalosis; in digitalis intoxication; and in patients with hypokalemic familial periodic paralysis. If hypokalemia is the result of diuretic therapy, consideration should be given to the use of a lower dose of diuretic, which may be sufficient without leading to hypokalemia.
2. For the prevention of hypokalemia in patients who would be at particular risk if hypokalemia were to develop, e.g., digitalized patients or patients with significant cardiac arrhythmias, hepatic cirrhosis with ascites, states of aldosterone excess with normal renal funsion, potassium losing nephropathy, and certain diarrheal states.
The use of potassium salts in patients receiving diuretics for uncomplicated essential hypertension is often unnecessary when such patients have a normal dietary pattern and when low doses of the diuretic are used. Serum potassium should be checked periodically, however, and if hypokalemia occurs, dietary supplementation with potassium-containing foods may be adequate to control milder cases. In more severe cases, and if dose adjustment of the diuretic is ineffective or unwarranted, supplementation with potassium salts may be indicated.
DOSAGE AND ADMINISTRATION
The usual dietary potassium intake by the average adult is 50 to 100 mEq per day. Potassium depletion sufficient to cause hypokalemia usually requires the loss of 200 or more mEq of potassium from the total body store.
Dosage must be adjusted to the individual needs of each patient. The dose for the prevention of the hypokalemia is typically in the range of 20 mEq per day. Doses of 40-100 mEq per day or more are used for the treatment of potassium depletion. Dosage should be divided if more than 20 mEq per day are given such that no more than 20 mEq is given in a single dose.
Usual Adult Dose: One Micro-K LS 20 mEq packet 1 to 5 times daily, depending on the requirements of the patient. This product must be suspended in a liquid, preferably water, or sprinkled on food prior to ingestion.
Suspension in Water: Pour contents of packet slowly into approximately 2-6 fluid ounces (1/4-3/4 glassful) of water. Stir thoroughly for approximately 1 minute until slightly thickened, then drink. The entire contents of the packet must be used immediately and not stored for future use. Any microcapsule/water mixture should be used immediately and not stored for future use.
Suspension in Liquids other than Water: Studies conducted using orange juice, tomato juice, apple juice and milk as the suspending liquid have shown that the quantity of fluid used to suspend one Micro-K LS packet MUST be limited to 2 fluid ounces (1/4 glassful). The use of volumes greater than 2 fluid ounces substantially reduces the dose of potassium chloride delivered. If a liquid other than water is used to suspend Micro-K LS, then the contents of the packet should be slowly poured into 2 fluid ounces (1/4 glassful) of liquid. Stir thoroughly for approximately 1 minute, then drink. The entire contents of the packet must be used immediately and not stored for future use. Any microcapsule/liquid mixture should be used immediately and not stored for future use.
Sprinkling Contents on Food: Micro-K LS may be given on soft food that may be swallowed easily without chewing, such as applesauce or pudding. After sprinkling the contents of the packet on the food, it should be swallowed immediately without chewing and followed with a glass of cool water, milk, or juice to ensure complete swallowing of all the microcapsules. Do not store microcapsule/food mixture for future use.
Each packet of Micro-K LS brand potassium chloride extended-release formulation for liquid suspension contains 1.5 g microencapsulated potassium chloride (equivalent to 20 mEq K), and is packaged as follows:
Carton of 30 packets
Carton of 100 packets
Store at controlled room temperature 25°C (77°F); excursions permitted to 15°-30°C (59°-86°F). [See USP Controlled Room Temperature.]
Last reviewed on RxList: 12/26/2005
This monograph has been modified to include the generic and brand name in many instances.
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