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In this Article

• What is glyburide (Micronase)?
• What are the possible side effects of glyburide (Micronase)?
• What is the most important information I should know about glyburide (Micronase)?
• What should I discuss with my health care provider before taking glyburide (Micronase)?
• How should I take glyburide (Micronase)?
• What happens if I miss a dose (Micronase)?
• What happens if I overdose (Micronase)?
• What should I avoid while taking glyburide (Micronase)?
• What other drugs will affect glyburide (Micronase)?
• Where can I get more information?

What happens if I miss a dose (Micronase)?

Take the missed dose as soon as you remember (be sure to take the medicine with food). If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose (Micronase)?

Seek emergency medical attention if you think you have used too much of this medicine. A glyburide overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

What should I avoid while taking glyburide (Micronase)?

Avoid drinking alcohol while taking glyburide. Alcohol can lower your blood sugar.

Avoid exposure to sunlight, sunlamps, or tanning beds. Glyburide can make your skin more sensitive to sunlight, and a sunburn may result. Wear protective clothing and use sunscreen (SPF 15 or higher) when you are outdoors.

What other drugs will affect glyburide (Micronase)?

Tell your doctor about all other medications you use, especially:

• a blood thinner such as warfarin (Coumadin);
• cyclosporine (Gengraf, Neoral, Sandimmune);
• disopyramide (Norpace);
• fluconazole (Diflucan), ketoconazole (Nizoral); or
• fluoxetine (Prozac);
• rifampin (Rifadin, Rimactane, Rifater);
• an ACE inhibitor such as enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others; or
• an antibiotic such as ciprofloxacin (Cipro), levofloxacin (Levaquin), and others.

Using certain medicines can make it harder for you to tell when you have low blood sugar. Tell your doctor if you use any of the following:

• albuterol (Proventil, Ventolin);
• clonidine (Catapres);
• reserpine;
• guanethidine (Ismelin); or
• beta-blockers such as atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), and others.

You may be more likely to have hyperglycemia (high blood sugar) if you are taking glyburide with other drugs that raise blood sugar, such as:

• isoniazid;
• diuretics (water pills);
• steroids (prednisone and others);
• phenothiazines (Compazine and others);
• thyroid medicine (Synthroid and others);
• birth control pills and other hormones;
• heart or blood pressure medications (Cartia, Cardizem, Nifedical, Covera, Verelan, and others);
• seizure medicines (Dilantin and others); and
• diet pills or medicines to treat asthma, colds or allergies.

You may be more likely to have hypoglycemia (low blood sugar) if you are taking glyburide with other drugs that lower blood sugar, such as:

• probenecid (Benemid);
• some nonsteroidal anti-inflammatory drugs (NSAIDs);
• aspirin or other salicylates (including Pepto-Bismol);
• sulfa drugs (Bactrim, Gantanol, Septra, and others); and
• a monoamine oxidase inhibitor (MAOI).

This list is not complete and there may be other drugs that can interact with glyburide. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about glyburide.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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