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In this Article

• What is glyburide (Micronase)?
• What are the possible side effects of glyburide (Micronase)?
• What is the most important information I should know about glyburide (Micronase)?
• What should I discuss with my health care provider before taking glyburide (Micronase)?
• How should I take glyburide (Micronase)?
• What happens if I miss a dose (Micronase)?
• What happens if I overdose (Micronase)?
• What should I avoid while taking glyburide (Micronase)?
• What other drugs will affect glyburide (Micronase)?
• Where can I get more information?

What should I discuss with my health care provider before taking glyburide (Micronase)?

You should not use this medication if you are allergic to glyburide, or:

• if you are being treated with bosentan (Tracleer);
• if you have type 1 (insulin-dependent) diabetes; or
• if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take glyburide:

• hemolytic anemia (a lack of red blood cells);
• an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);
• a nerve disorder affecting bodily functions;
• liver or kidney disease;
• if you are allergic to sulfa drugs; or
• if you have been using insulin or taking chlorpropamide (Diabinese).

Taking certain oral diabetes medication may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with glyburide.

FDA pregnancy category C. It is not known whether glyburide is harmful to an unborn baby. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether glyburide passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Older adults may be more likely to have low blood sugar while taking glyburide.

How should I take glyburide (Micronase)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Take glyburide with your first meal of the day, unless your doctor tells you otherwise.

Your blood sugar will need to be checked on a regular basis. You may also need other blood tests at your doctor's office. Do not miss any appointments.

Your dose needs may change if you become ill, have a fever or infection, or if you have surgery or a medical emergency. Your doctor may want you to stop taking glyburide for a short time if any of these situations affect you.

Take care not to let your blood sugar get too low, causing hypoglycemia. You may have hypoglycemia if you skip a meal, exercise too long, drink alcohol, or are under stress.

Know the signs of low blood sugar (hypoglycemia) and how to recognize them: hunger, headache, confusion, irritability, drowsiness, weakness, dizziness, tremors, sweating, fast heartbeat, seizure, or fainting (severe hypoglycemia can be fatal).

Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.

If your blood sugar gets too high (hyperglycemia), you may feel very thirsty or hungry. You may also urinate more than usual. Call your doctor right away if you have any symptoms of hyperglycemia.

If there are any changes in the brand, strength, or type of glyburide you use, your dosage needs may change. Always check your refills to make sure you have received the correct brand and type of medicine prescribed by your doctor. Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy.

Glyburide is only part of a complete program of treatment that also includes diet, exercise, and weight control. It is important to use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Store glyburide at room temperature, protected from moisture, heat, and light.