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MICROZIDE (hydrochlorothiazide capsule) is indicated in the management of hypertension either as the sole therapeutic agent, or in combination with other antihypertensives. Unlike potassium sparing combination diuretic products, MICROZIDE (hydrochlorothiazide capsule) may be used in those patients in whom the development of hyperkalemia cannot be risked, including patients taking ACE inhibitors.
Usage in Pregnancy
The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia.
Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancy. Diuretics are indicated in pregnancy when edema is due to pathologic causes, just as they are in the absence of pregnancy. Dependent edema in pregnancy resulting from restriction of venous return by the expanded uterus is properly treated through elevation of the lower extremities and use of support hose; use of diuretics to lower intravascular volume in this case is illogical and unnecessary. There is hypervolemia during normal pregnancy which is harmful to neither the fetus nor the mother (in the absence of cardiovascular disease), but which is associated with edema, including generalized edema in the majority of pregnant women. If this edema produces discomfort, increased recumbency will often provide relief. In rare instances this edema may cause extreme discomfort which is not relieved by rest. In these cases a short course of diuretics may provide relief and may be appropriate.
DOSAGE AND ADMINISTRATION
For Control of Hypertension: The adult initial dose of MICROZIDE (hydrochlorothiazide capsule) is one capsule given once daily whether given alone or in combination with other antihypertensives. Total daily doses greater than 50 mg are not recommended.
MICROZIDE (hydrochlorothiazide capsule) Capsules are #4 Teal Opaque/Teal Opaque two piece hard gelatin capsules imprinted with MICROZIDE (hydrochlorothiazide capsule) and 12.5 mg in black ink. They are supplied in bottles of 100 with child resistant closures
Dispense in a tight, light-resistant container as defined in the USP.
Keep out of reach of children.
Store at 20°-25°C (68°-77°F). [See USP controlled room temperature.] Protect from light, moisture, freezing, -20°C (-4°F). Keep container tightly closed.
Address medical inquiries to: WATSON., Medical Communications P.O. Box 1953, Morristown, NJ 07962-1953. 800-272-5525. Manufactured By: Watson Pharma Private Limited. Verna, Salcette, Goa 403 722 INDIA. Distributed By: Watson Pharma, Inc. Morristown, NJ 07962 USA. Revised: February 2011
Last reviewed on RxList: 5/10/2011
This monograph has been modified to include the generic and brand name in many instances.
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