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Midamor

Last reviewed on RxList: 5/19/2008
Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Midamor Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 12/1/2015

Midamor (amiloride HCl) is an antikaliuretic diuretic agent indicated as adjunctive treatment with thiazide diuretics or other kaliuretic-diuretic agents in congestive heart failure or hypertension. Midamor is no longer available in the U.S. Generic versions may still be available. Side effects of Miamor (amiloride HCl) include numbness or tingly feeling, muscle pain or weakness, slow, fast, or uneven heartbeat, headache, nausea, loss of appetite, stomach pain, gas, or skin rash. Serious side effects include high blood potassium (hyperkalemia).

Midamor was available in 5 mg tablets. Midamor should be administered with food. One 5 mg tablet daily, should be added to the usual antihypertensive or diuretic dosage of a kaliuretic diuretic. The dosage may be increased to 10 mg per day if necessary. Midamor may interact with cyclosporine, tacrolimus, lithium, ACE inhibitors, or indomethacin or other NSAIDs (nonsteroidal anti-inflammatory drugs). Tell your doctor all medications and supplements you use. There are no adequate and well-controlled studies in pregnant women or pediatric patients. The drug should be used during pregnancy only if clearly needed. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Our Miamor (amiloride HCl) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Midamor Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • numbness or tingly feeling;
  • muscle pain or weakness;
  • slow, fast, or uneven heartbeat;
  • feeling drowsy, restless, or light-headed;
  • urinating less than usual or not at all;
  • dry mouth, increased thirst, tiredness, nausea, vomiting;
  • shallow breathing;
  • tremors, confusion; or
  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • headache;
  • mild nausea, loss of appetite;
  • gas, stomach pain; or
  • skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Midamor (Amiloride)

Midamor Professional Information

SIDE EFFECTS

MIDAMOR (amiloride) is usually well tolerated and except for hyperkalemia (serum potassium levels greater than 5.5 mEq per liter † see BOXED WARNING), significant adverse effects have been reported infrequently. Minor adverse reactions were reported relatively frequently (about 20%) but the relationship of many of the reports to amiloride HCl is uncertain and the overall frequency was similar in hydrochlorothiazide treated groups. Nausea/anorexia, abdominal pain, flatulence, and mild skin rash have been reported and probably are related to amiloride. Other adverse experiences that have been reported with amiloride are generally those known to be associated with diuresis, or with the underlying disease being treated.

The adverse reactions for MIDAMOR (amiloride) listed in the following table have been arranged into two groups: (1) incidence greater than one percent; and (2) incidence one percent or less. The incidence for group (1) was determined from clinical studies conducted in the United States (837 patients treated with MIDAMOR (amiloride) ). The adverse effects listed in group (2) include reports from the same clinical studies and voluntary reports since marketing. The probability of a causal relationship exists between MIDAMOR (amiloride) and these adverse reactions, some of which have been reported only rarely.

Incidence >1% Incidence ≤ 1%
Body as a Whole
Headache**
Weakness
Fatigability
Back pain
Chest pain
Neck/shoulder ache
Pain, extremities
Cardiovascular
None Angina pectoris
Orthostatic hypotension
Arrhythmia
Palpitation
Digestive
Nausea/anorexia**
Diarrhea**
Vomiting**
Abdominal pain
Gas pain
Appetite changes
Constipation
Jaundice
GI bleeding
Abdominal fullness
GI disturbance
Thirst
Heartburn
Flatulence
Dyspepsia
Metabolic
Elevated serum potassium levels (> 5.5 mEq per Liter)*** None
Skin
None Skin rash
Itching
Dryness of mouth
Pruritus
Alopecia
Musculoskeletal
Muscle cramps Joint pain
Leg ache
Nervous
Dizziness
Encephalopathy
Paresthesia
Tremors
Vertigo
Psychiatric
None Nervousness
Mental confusion
Insomnia
Decreased libido
Depression
Somnolence
Respiratory
Cough
Dyspnea
Shortness of breath
Special Senses
None Visual disturbances
Nasal congestion
Tinnitus
Increased intraocular pressure
Urogenital
Impotence Polyuria
Dysuria
Urinary frequency
Bladder spasms
Gynecomastia

** Reactions occurring in 3% to 8% of patients treated with MIDAMOR (amiloride) . (Those reactions occurring in less than 3% of the patients are unmarked.)
*** See BOXED WARNING.

Causal Relationship Unknown: Other reactions have been reported but occurred under circumstances where a causal relationship could not be established. However, in these rarely reported events, that possibility cannot be excluded. Therefore, these observations are listed to serve as alerting information to physicians.

Read the entire FDA prescribing information for Midamor (Amiloride)

Related Resources for Midamor

Read the Midamor User Reviews »

© Midamor Patient Information is supplied by Cerner Multum, Inc. and Midamor Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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