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Midrin

Migraine medications overview

Migraine is a serious, potentially life-threatening neurological disease that affects nearly 32 million Americans, the majority of whom are women. The hallmark symptom of migraine is an escalating, often unbearable, debilitating headache that is commonly described as intense throbbing or pulsating pain in one area of the head. The pain may be accompanied by extreme sensitivity to light and sound, nausea, and vomiting. In some people, migraines are preceded by visual disturbances known as auras that may include flashing lights, zigzag lines, or temporary blindness.

Migraine medications do not cure migraines. Instead, migraine drugs treat the symptoms using one of two approaches. Some migraine drugs relieve symptoms. Other migraine drugs are used to prevent a migraine attack.

Many migraine sufferers rely on simple pain relievers to get through an attack. These range from over-the-counter analgesics like acetaminophen to an...

Midrin

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Midrin Drug Center

Medical Editor: John P. Cunha, DO, FACOEP

Midrin (isometheptene mucate, dichloralphenazone and acetaminophen) is used to treat migraine headaches or severe tension headaches. It is a combination of three drugs: acetaminophen, a pain reliever and fever reducer; dichloralphenazone, a sedative; and isometheptene, a vasoconstrictor. Midrin is no longer manufactured, but equivalents (medications that contain the same drug combination) may be available. Consult your doctor and pharmacist. Common side effects include dizziness, drowsiness, and nausea.

The usual adult dosage of Midrin is two capsules at once, followed by one capsule every hour until relieved, up to 5 capsules within a 12-hour period. Midrin or equivalent medications may interact with blood thinners, isoniazid, or antidepressants. Acetaminophen is contained in many combination medicines. Read all labels carefully so you don't take too much acetaminophen. Tell your doctor all medications you are taking. During pregnancy, this medication should be used only when prescribed. Discuss the risks and benefits with your doctor. This medication passes into breast milk. Consult your doctor before breast-feeding.

Our Midrin (isometheptene mucate, dichloralphenazone and acetaminophen) Drug Center provides a comprehensive view of available drug information as well as related drugs, user reviews, supplements, and diseases and conditions articles.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Midrin Prescribing Information: Indications & Dosage

For relief of tension and vascular headaches*.

*Based on a review of this drug (isometheptene mucate) by the National Academy of Sciences-National Research Council and/or other information, FDA has classified the other indication as "possibly" effective in the treatment of migraine headache. Final classification of the less-than-effective indication requires further investigation.

Read the complete drug monograph for Midrin »

What is Patient information?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Midrin Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using acetaminophen, dichloralphenazone, and isometheptene and call your doctor at once if you have a serious side effect such as:

  • low fever with nausea, stomach pain, and loss of appetite;
  • dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • fast or uneven heart rate;
  • easy bruising or bleeding, unusual weakness; or
  • fever, chills, sor...

Read the complete patient information for Midrin »

What is Consumer information?

A concise overview of the drug for the patient or caregiver from First DataBank.

Midrin Consumer Information: Uses

This combination medication is used to relieve tension and migraine headaches. Acetaminophen helps to decrease the pain from the headache. Isometheptene helps to narrow the widened blood vessels in the head. Headache pain can be caused by these widened blood vessels. Dichloralphenazone helps to relax the body.

HOW TO USE: Take this medication by mouth with or without food as directed by your doctor.

Dosage is based on your medical condition and response to therapy.

For migraine headaches, take at the first sign of the headache as directed by y...

Read the complete consumer information for Midrin »

What is Midrin Consumer Information?

Warnings - Uses - How to Use - Side Effects - Precautions - Drug Interactions and More

Midrin - User Reviews

Midrin User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Midrin sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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