Midrin (Acetaminophen, Isometheptene and Dichloralphenazone) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Midrin

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What is a migraine headache?

A migraine headache is a form of vascular headache. Migraine headache is caused by vasodilatation (enlargement of blood vessels) that causes the release of chemicals from nerve fibers that coil around the large arteries of the brain. Enlargement of these blood vessels stretches the nerves that coil around them and causes the nerves to release chemicals. The chemicals cause inflammation, pain, and further enlargement of the artery. The increasing enlargement of the arteries magnifies the pain.

Migraine attacks commonly activate the sympathetic nervous system in the body. The sympathetic nervous system is often thought of as the part of the nervous system that controls primitive responses to stress and pain, the so-called "fight or flight" response, and this activation causes many of the symptoms associated with migraine attacks; for example, the increased sympathetic nervous activity in the intestine causes nausea, vomiting,...

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Midrin

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MIDRIN®
(isometheptene mucate, dichloralphenazone and acetaminophen)

DRUG DESCRIPTION

Each red capsule contains Isometheptene Mucate USP, 65 mg, Dichloralphenazone USP, 100 mg, and Acetaminophen USP, 325 mg.

Isometheptene Mucate is a white crystalline powder having a characteristic aromatic odor and bitter taste. It is an unsaturated aliphatic amine with sympathomimetic properties.

Dichloralphenazone is a white, microcrystalline powder, with slight odor and tastes saline at first, becoming acrid. It is a mild sedative.

Acetaminophen, a non-salicylate, occurs as a white, odorless, crystalline powder, possessing a slightly bitter taste.

Midrin (acetaminophen, isometheptene and dichloralphenazone) capsules contain FD&C Yellow No. 6 as a color additive.

What are the possible side effects of acetaminophen, dichloralphenazone, and isometheptene?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using acetaminophen, dichloralphenazone, and isometheptene and call your doctor at once if you have a serious side effect such as:

low fever with nausea, stomach pain, and loss of appetite;
dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
fast or uneven heart rate;
easy...

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What are the precautions when taking acetaminophen, isometheptene and dichloralphenazone (Midrin)?

Before taking this medication, tell your doctor or pharmacist if you are allergic to acetaminophen, isometheptene, or dichloralphenazone; or to chloral hydrate; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: a certain eye disease (glaucoma).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart/blood vessel disease (e.g., coronary artery disease, stroke, recent heart attack), kidney disease, liver disease, high blood pressure, history of drug...

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Last reviewed on RxList: 6/26/2008
This monograph has been modified to include the generic and brand name in many instances.