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Midrin Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking acetaminophen, dichloralphenazone, and isometheptene?

Do not take this medication if you have taken a monoamine oxidase inhibitor (MAOI) such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the last 14 days. Dangerous side effects could result.

You should not take this medication if you are allergic to acetaminophen (Tylenol), dichloralphenazone, isometheptene, or chloral hydrate (Somnote), or if you have:

  • glaucoma; or
  • if you are also taking sodium oxybate (Xyrem).

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:

  • liver disease;
  • kidney disease;
  • coronary artery disease, circulation problems;
  • high blood pressure;
  • stomach ulcer or problems with your esophagus;
  • depression;
  • a history of drug or alcohol addiction; or
  • if you have recently had a stroke or heart attack.

FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby. Before you take acetaminophen, dichloralphenazone, and isometheptene, tell your doctor if you are pregnant.

This medication can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take acetaminophen, dichloralphenazone, and isometheptene?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Do not use more of this medication than is recommended. An overdose of acetaminophen can cause serious harm. The maximum amount for adults is 1 gram (1000 mg) per dose and 4 grams (4000 mg) per day. Using more acetaminophen could cause damage to your liver. If you drink more than three alcoholic beverages per day, talk to your doctor before taking acetaminophen and never use more than 2 grams (2000 mg) per day.

You may take this medication with or without food.

Take the medicine with a full glass of water.

To treat migraine headache pain:

  • Take the first dose of this medication as soon as you notice headache symptoms, or after an attack has already begun.
  • If your headache does not completely go away, take 1 capsule every hour until you feel relief.
  • Do not take more than a total of 5 capsules in any 12-hour period to treat a migraine.
  • If you still have migraine symptoms after taking a total of 5 capsules, call your doctor.

To treat tension headache pain:

  • Take the first dose of this medication as soon as you notice tension headache symptoms.
  • If your headache does not completely go away, take 1 capsule every 4 hours until you feel relief.
  • Do not take more than a total of 8 capsules in any 24-hour period to treat a tension headache.
  • If you still have tension headache pain after taking a total of 8 capsules, call your doctor.

Call your doctor if this medication seems to stop working as well in relieving your pain. Also call your doctor if your headaches get worse or you have more than 2 headaches per week.

Do not stop using this medication suddenly if you have been using it for longer than 2 weeks in a row, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when you stop using acetaminophen, dichloralphenazone, and isometheptene.

If you need to have any type of surgery, tell the surgeon ahead of time that you are using this medication.

This medication can cause you to have unusual results with certain lab tests, including tests to check for glucose (sugar) in the urine. Tell any doctor who treats you that you are using acetaminophen, dichloralphenazone, and isometheptene.

Store this medication at room temperature away from heat, moisture, and light.

Side Effects Centers

Midrin - User Reviews

Midrin User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Midrin sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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