April 30, 2017
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Midrin Patient Information Including Side Effects

Brand Names: Epidrin, Midrin, Migquin, Migragesic IDA

Generic Name: acetaminophen, dichloralphenazone, and isometheptene (Pronunciation: a SEET a MIN oh fen, dye KLOR al FEN a zone, EYE soe me THEP teen)

What is acetaminophen, dichloralphenazone, and isometheptene (Midrin)?

Acetaminophen is a pain reliever and a fever reducer.

Dichloralphenazone is a sedative that slows the central nervous system.

Isometheptene causes narrowing of blood vessels (vasoconstriction).

The combination of acetaminophen, dichloralphenazone, and isometheptene is used to treat migraine headaches or severe tension headaches.

Acetaminophen, dichloralphenazone, and isometheptene may also be used for purposes not listed in this medication guide.


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What are the possible side effects of acetaminophen, dichloralphenazone, and isometheptene (Midrin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using the medicine and call your doctor at once if you have a serious side effect such as:

  • low fever with nausea, stomach pain, and loss of appetite;
  • dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • fast or uneven heart rate;
  • easy bruising or bleeding, unusual weakness; or
  • fever, chills, sore throat, body aches, flu symptoms.

Less serious side effects may include:

  • dizziness, drowsiness;
  • mild nausea; or
  • mood changes.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Midrin (acetaminophen, isometheptene and dichloralphenazone) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about acetaminophen, dichloralphenazone, and isometheptene (Midrin)?

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

Tell your doctor if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen.

Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

You should not take acetaminophen, dichloralphenazone, and isometheptene if you are allergic to acetaminophen (Tylenol), dichloralphenazone, isometheptene, or chloral hydrate (Somnote), or if you have glaucoma or if you are also taking sodium oxybate (Xyrem).

Do not take more than 5 capsules in 12 hours to treat a migraine, or 8 capsules in 24 hours to treat a tension headache.

Ask a doctor or pharmacist before using any other pain, cold, allergy, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

Do not use acetaminophen, dichloralphenazone, and isometheptene if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Side Effects Centers

Midrin - User Reviews

Midrin User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Midrin sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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