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Midrin Patient Information Including Side Effects

Brand Names: Duradrin, Epidrin, Isocom, Midrin, Migquin, Migrapap, Migratine, Migrazone

Generic Name: acetaminophen, dichloralphenazone, and isometheptene (Pronunciation: a SEET a MIN oh fen, dye KLOR al FEN a zone, EYE soe me THEP teen)

What is acetaminophen, dichloralphenazone, and isometheptene (Midrin)?

Acetaminophen is a pain reliever and a fever reducer.

Dichloralphenazone is a sedative that slows the central nervous system.

Isometheptene causes narrowing of blood vessels (vasoconstriction).

The combination of acetaminophen, dichloralphenazone, and isometheptene is used to treat migraine headaches or severe tension headaches.

Acetaminophen, dichloralphenazone, and isometheptene may also be used for other purposes not listed in this medication guide.


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What are the possible side effects of acetaminophen, dichloralphenazone, and isometheptene?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using acetaminophen, dichloralphenazone, and isometheptene and call your doctor at once if you have a serious side effect such as:

  • low fever with nausea, stomach pain, and loss of appetite;
  • dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • fast or uneven heart rate;
  • easy bruising or bleeding, unusual weakness; or
  • fever, chills, sore throat, body aches, flu symptoms.

Less serious side effects may include:

  • dizziness, drowsiness;
  • mild nausea; or
  • mood changes.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Midrin (acetaminophen, isometheptene and dichloralphenazone) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about acetaminophen, dichloralphenazone, and isometheptene?

Do not take this medication if you have taken a monoamine oxidase inhibitor (MAOI) such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the last 14 days. Dangerous side effects could result.

You should not take this medication if you are allergic to acetaminophen (Tylenol), dichloralphenazone, isometheptene, or chloral hydrate (Somnote), or if you have glaucoma or if you are also taking sodium oxybate (Xyrem).

Before taking acetaminophen, dichloralphenazone, and isometheptene, tell your doctor if you have liver or kidney disease, coronary artery disease, circulation problems, high blood pressure, stomach ulcer, problems with your esophagus, depression, a history of drug or alcohol addiction, or if you have recently had a stroke or heart attack.

Avoid drinking alcohol. Alcohol can cause headaches, and may also increase your risk of liver damage while taking acetaminophen.

If you drink more than 3 alcoholic beverages per day, talk with your doctor before taking any medication that contains acetaminophen. Alcohol may increase your risk of liver damage while taking acetaminophen.

Do not use any cold, allergy, pain, migraine, or sleep medication without first asking your doctor or pharmacist. Acetaminophen (sometimes abbreviated as "APAP") is contained in many combination medicines. If you use certain products together you may accidentally use too much acetaminophen. Read the label of any other medicine you are using to see if it contains acetaminophen, or APAP.

Side Effects Centers

Midrin - User Reviews

Midrin User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Midrin sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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