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Migranal

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Migranal

MIGRANAL
(dihydroergotamine mesylate) Spray

Migranal

WARNING

Serious and/or life-threatening peripheral ischemia has been associated with the coadministration of DIHYDROERGOTAMINE with potent CYP 3A4 inhibitors including protease inhibitors and macrolide antibiotics. Because CYP 3A4 inhibition elevates the serum levels of DIHYDROERGOTAMINE, the risk for vasospasm leading to cerebral ischemia and/or ischemia of the extremities is increased. Hence, concomitant use of these medications is contraindicated. (See also CONTRAINDICATIONS and WARNINGS section)

DRUG DESCRIPTION

Migranal (dihydroergotamine mesylate spray) ® is ergotamine hydrogenated in the 9,10 position as the mesylate salt. Migranal (dihydroergotamine mesylate spray) ® is known chemically as ergotaman-3', 6', 18-trione, 9,10-dihydro-12'-hydroxy-2'-methyl-5'- (phenylmethyl)-, (5'α)-, monomethanesulfonate. Its molecular weight is 679.80 and its empirical formula is C33H37N5O5•CH4O3S.

The chemical structure is:

 MIGRANAL (dihydroergotamine mesylate) Structural Formula Illustration

C33H37N5O5•CH4O3S       Mol. wt. 679.80

MigranaI® (dihydroergotamine mesylate, USP) Nasal Spray is provided for intranasal administration as a clear, colorless to faintly yellow solution in an amber glass vial containing:

dihydroergotamine mesylate, USP....................................4.0 mg
caffeine, anhydrous, USP.................................................10.0 mg
dextrose, anhydrous, USP ...............................................50.0 mg
carbon dioxide, USP.........................................................qs
purified water, USP..........................................................qs 1.0 mL

What are the possible side effects of dihydroergotamine nasal (Migranal)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using dihydroergotamine and call your doctor at once if you have a serious side effect such as:

  • fast or slow heart rate;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, and nausea, sweating, or general ill feeling;
  • sudden numbness or weakness, sudden headache, confusion, or problems with vision, speech, or balance;
  • muscle pain in your arms or legs,...

Read All Potential Side Effects and See Pictures of Migranal »

Last reviewed on RxList: 5/11/2009
This monograph has been modified to include the generic and brand name in many instances.

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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