Migranal (Dihydroergotamine Mesylate Spray) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 27, 2012

Migranal

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Migranal

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MIGRANAL
(dihydroergotamine mesylate) Spray

WARNING

Serious and/or life-threatening peripheral ischemia has been associated with the coadministration of DIHYDROERGOTAMINE with potent CYP 3A4 inhibitors including protease inhibitors and macrolide antibiotics. Because CYP 3A4 inhibition elevates the serum levels of DIHYDROERGOTAMINE, the risk for vasospasm leading to cerebral ischemia and/or ischemia of the extremities is increased. Hence, concomitant use of these medications is contraindicated. (See also CONTRAINDICATIONS and WARNINGS section)

DRUG DESCRIPTION

Migranal (dihydroergotamine mesylate spray) ® is ergotamine hydrogenated in the 9,10 position as the mesylate salt. Migranal (dihydroergotamine mesylate spray) ® is known chemically as ergotaman-3', 6', 18-trione, 9,10-dihydro-12'-hydroxy-2'-methyl-5'- (phenylmethyl)-, (5'α)-, monomethanesulfonate. Its molecular weight is 679.80 and its empirical formula is C₃₃H₃₇N₅O₅•CH₄O₃S.

The chemical structure is:

MIGRANAL (dihydroergotamine mesylate) Structural Formula Illustration

C₃₃H₃₇N₅O₅•CH₄O₃S Mol. wt. 679.80

MigranaI® (dihydroergotamine mesylate, USP) Nasal Spray is provided for intranasal administration as a clear, colorless to faintly yellow solution in an amber glass vial containing:

dihydroergotamine mesylate, USP....................................4.0 mg
caffeine, anhydrous, USP.................................................10.0 mg
dextrose, anhydrous, USP ...............................................50.0 mg
carbon dioxide, USP.........................................................qs
purified water, USP..........................................................qs 1.0 mL

Last reviewed on RxList: 5/11/2009
This monograph has been modified to include the generic and brand name in many instances.