Migranal
Prescription Migraine Medications »
"Migraine medications overview
Migraine is a serious, potentially life-threatening neurological disease that affects nearly 32 million Americans, the majority of whom are women. The hallmark symptom of migraine is an escalating, often "...
Migranal
MIGRANAL
(dihydroergotamine mesylate) Spray
WARNING
Serious and/or life-threatening peripheral ischemia has been associated with the coadministration of DIHYDROERGOTAMINE with potent CYP 3A4 inhibitors including protease inhibitors and macrolide antibiotics. Because CYP 3A4 inhibition elevates the serum levels of DIHYDROERGOTAMINE, the risk for vasospasm leading to cerebral ischemia and/or ischemia of the extremities is increased. Hence, concomitant use of these medications is contraindicated. (See also CONTRAINDICATIONS and WARNINGS section)
DRUG DESCRIPTION
Migranal (dihydroergotamine mesylate spray) ® is ergotamine hydrogenated in the 9,10 position as the mesylate salt. Migranal (dihydroergotamine mesylate spray) ® is known chemically as ergotaman-3', 6', 18-trione, 9,10-dihydro-12'-hydroxy-2'-methyl-5'- (phenylmethyl)-, (5'α)-, monomethanesulfonate. Its molecular weight is 679.80 and its empirical formula is C33H37N5O5•CH4O3S.
The chemical structure is:
 |
C33H37N5O5•CH4O3S Mol. wt. 679.80
MigranaI® (dihydroergotamine mesylate, USP) Nasal Spray is provided for intranasal administration as a clear, colorless to faintly yellow solution in an amber glass vial containing:
dihydroergotamine mesylate, USP....................................4.0 mg
caffeine, anhydrous, USP.................................................10.0
mg
dextrose, anhydrous, USP ...............................................50.0
mg
carbon dioxide, USP.........................................................qs
purified water, USP..........................................................qs
1.0 mL
Last reviewed on RxList: 5/11/2009
This monograph has been modified to include the generic and brand name in many instances.
Additional Migranal Information
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