May 23, 2017
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Migranal Patient Information Including Side Effects

Brand Names: Migranal

Generic Name: dihydroergotamine (nasal) (Pronunciation: dye HYE droe er GOT a meen)

What is dihydroergotamine nasal (Migranal)?

Dihydroergotamine is in a group of drugs called ergot alkaloids (ER-got AL-ka-loids). It works by narrowing the blood vessels around the brain.

Dihydroergotamine nasal is used to a treat migraine headache attack.

This medication will only treat a migraine headache that has already begun. It will not prevent headaches or reduce the number of attacks.

Dihydroergotamine nasal should not be used to treat common tension headaches or any headache that seems to be different from your usual migraine headaches.

Dihydroergotamine nasal may also be used for other purposes not listed in this medication guide.

What are the possible side effects of dihydroergotamine nasal (Migranal)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using dihydroergotamine and call your doctor at once if you have a serious side effect such as:

  • fast or slow heart rate;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, and nausea, sweating, or general ill feeling;
  • sudden numbness or weakness, sudden headache, confusion, or problems with vision, speech, or balance;
  • muscle pain in your arms or legs, leg weakness;
  • numbness or tingling and a pale or blue-colored appearance in your fingers or toes;
  • swelling or itching in any part of your body;
  • stomach cramps, diarrhea that may be bloody;
  • cough with stabbing chest pain and trouble breathing; or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Less serious side effects may include:

  • pain, soreness, burning, tingling, or dryness in your nose or throat;
  • runny or stuffy nose, nosebleeds;
  • changes in your sense of taste;
  • headache, dizziness, drowsiness;
  • feeling anxious or depressed;
  • cold sweats; or
  • nausea, vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Migranal (dihydroergotamine mesylate spray) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about dihydroergotamine nasal (Migranal)?

This medication can harm an unborn baby or a nursing baby. Do not use dihydroergotamine nasal if you are pregnant or breast-feeding.

Do not use this medication if you are allergic to dihydroergotamine or other ergot medicines, or if you have a history of heart disease, angina (chest pain), blood circulation problems, history of a heart attack or stroke, coronary artery disease, uncontrolled high blood pressure, severe liver or kidney disease, a serious infection, if you have recently had heart or blood vessel surgery.

Using certain medications together with dihydroergotamine can cause severe decreases in blood flow and lead to dangerous side effects. Tell your doctor about all other medications you are using, especially antibiotics, antidepressants, heart or blood pressure medications, or medicines to treat HIV or AIDS.

Also tell your doctor about all of your medical conditions, especially breathing problems, high blood pressure, ischemic bowel disease, liver or kidney disease, or risk factors for coronary artery disease (such as diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).

Side Effects Centers

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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