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Minipress Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Minipress (prazosin hydrochloride) is used to treat hypertension (high blood pressure). It is in a group of drugs called alpha-adrenergic blockers. Common side effects include headache, drowsiness, tiredness, weakness, blurred vision, nausea, vomiting, diarrhea, or constipation as your body adjusts to the medication. Lightheadedness or dizziness upon standing may also occur, especially after the first dose and shortly after taking a dose of the drug during the first week of treatment.
Initial dose of Minipress is 1 mg two or three times a day. The usual therapeutic dose ranges from 6 mg to 15 mg daily given in divided doses. Minipress may interact with digoxin, sildenafil, tadalafil, vardenafil, gout medication, heart rhythm medication, other blood pressure medications, diuretics (water pills), pain, fever, or arthritis medication such as aspirin, indomethacin, insulin or diabetes medication you take by mouth, or sedatives. Tell your doctor all medications you are taking. During pregnancy, Minipress should be used only when prescribed. Minipress passes into breast milk. Consult your doctor before breast-feeding.
Our Minipress (prazosin hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Minipress in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- fast or pounding heartbeats or fluttering in your chest;
- feeling like you might pass out;
- trouble breathing;
- swelling in your hands, ankles, or feet; or
- penis erection that is painful or lasts 4 hours or longer.
Less serious side effects may include:
- mild dizziness;
- weakness, tired feeling, drowsiness;
- headache; or
Read the entire detailed patient monograph for Minipress (Prazosin HCl) »
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Minipress Overview - Patient Information: Side Effects
Lightheadedness or dizziness upon standing may also occur, especially after the first dose and shortly after taking a dose of the drug during the first week of treatment. To reduce the risk of dizziness and fainting, get up slowly when rising from a seated or lying position. If dizziness occurs, sit or lie down immediately. Your dose may need to be adjusted.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: pounding heartbeat, fainting, frequent urination, mental/mood changes (such as depression), swelling of the feet/ankles.
For males, in the very unlikely event you have a painful, prolonged erection (lasting more than 4 hours), stop using this drug and seek immediate medical attention, or permanent problems could occur.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Minipress (Prazosin HCl)»
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Minipress FDA Prescribing Information: Side Effects
Clinical trials were conducted on more than 900 patients. During these trials and subsequent marketing experience, the most frequent reactions associated with MINIPRESS therapy are: dizziness 10.3%, headache 7.8%, drowsiness 7.6%, lack of energy 6.9%, weakness 6.5%, palpitations 5.3%, and nausea 4.9%. In most instances, side effects have disappeared with continued therapy or have been tolerated with no decrease in dose of drug.
Less frequent adverse reactions which are reported to occur in 1-4% of patients are:
Gastrointestinal: vomiting, diarrhea, constipation.
Central Nervous System: vertigo, depression, nervousness.
Genitourinary: urinary frequency.
In addition, fewer than 1% of patients have reported the following (in some instances, exact causal relationships have not been established):
Gastrointestinal: abdominal discomfort and/or pain, liver function abnormalities, pancreatitis.
Central Nervous System: paresthesia, hallucinations.
Other: diaphoresis, fever, positive ANA titer, arthralgia.
Single reports of pigmentary mottling and serous retinopathy, and a few reports of cataract development or disappearance have been reported. In these instances, the exact causal relationship has not been established because the baseline observations were frequently inadequate.
In more specific slit-lamp and funduscopic studies, which included adequate baseline examinations, no drug-related abnormal ophthalmological findings have been reported.
Literature reports exist associating MINIPRESS therapy with a worsening of pre-existing narcolepsy. A causal relationship is uncertain in these cases.
In post-marketing experience, the following adverse events have been reported:
Autonomic Nervous System: flushing.
Heart Rate/Rhythm: bradycardia.
Vascular (Extracardiac): vasculitis.
Vision: eye pain.
Special Senses: During cataract surgery, a variant of small pupil syndrome known as Intraoperative Floppy Iris Syndrome (IFIS) has been reported in association with alpha-1 blocker therapy (see PRECAUTIONS).
Read the entire FDA prescribing information for Minipress (Prazosin HCl) »
Additional Minipress Information
Minipress - User Reviews
Minipress User Reviews
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Get tips on handling your hypertension.