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Minoxidil

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Minoxidil

Minoxidil
(minoxidil) Tablets, USP

WARNING

Minoxidil tablets contain the powerful antihypertensive agent, minoxidil (minoxidil (minoxidil (minoxidil tablets) tablets) tablets) , which may produce serious adverse effects. It can cause pericardial effusion, occasionally progressing to tamponade, and angina pectoris may be exacerbated. Minoxidil (minoxidil (minoxidil (minoxidil tablets) tablets) tablets) should be reserved for hypertensive patients who do not respond adequately to maximum therapeutic doses of a diuretic and two other antihypertensive agents.

In experimental animals, minoxidil (minoxidil (minoxidil (minoxidil tablets) tablets) tablets) caused several kinds of myocardial lesions as well as other adverse cardiac effects (see Cardiac Lesions in Animals).

Minoxidil (minoxidil (minoxidil (minoxidil tablets) tablets) tablets) must be administered under close supervision, usually concomitantly with therapeutic doses of a beta-adrenergic blocking agent to prevent tachycardia and increased myocardial workload. It must also usually be given with a diuretic, frequently one acting in the ascending limb of the loop of Henle, to prevent serious fluid accumulation. Patients with malignant hypertension and those already receiving guanethidine (see WARNINGS) should be hospitalized when minoxidil (minoxidil (minoxidil (minoxidil tablets) tablets) tablets) is first administered so that they can be monitored to avoid too rapid, or large orthostatic, decreases in blood pressure.

DRUG DESCRIPTION

Minoxidil tablets contain minoxidil (minoxidil (minoxidil (minoxidil tablets) tablets) tablets) , an antihypertensive peripheral vasodilator. Minoxidil (minoxidil (minoxidil (minoxidil tablets) tablets) tablets) occurs as a white to off-white, crystalline powder, soluble in alcohol and propylene glycol; sparingly soluble in methanol; slightly soluble in water; practically insoluble in chloroform, acetone and ethyl acetate. The chemical name for minoxidil (minoxidil (minoxidil (minoxidil tablets) tablets) tablets) is 2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide. The structural formula is represented below:

Minoxidil  Structural Formula Illustration

C9H15N5O........M.W. 209.25

Minoxidil (minoxidil (minoxidil (minoxidil tablets) tablets) tablets) tablets for oral administration contain either 2.5 mg or 10 mg of minoxidil.

Minoxidil (minoxidil (minoxidil (minoxidil tablets) tablets) tablets) Tablets USP 2.5 mg and 10 mg contain the following inactive ingredients: anhydrous lactose, docusate sodium, magnesium stearate, microcrystalline cellulose, sodium benzoate and sodium starch glycolate.

What are the possible side effects of minoxidil (Loniten)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • dry cough, sharp or stabbing chest pain;
  • chest pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • trouble breathing (especially while lying down);
  • swelling in your legs, ankles, or feet;
  • rapid weight gain of 5 pounds or more;
  • fast or pounding heartbeats;
  • sudden numbness,...

Read All Potential Side Effects and See Pictures of Minoxidil »

Last reviewed on RxList: 6/25/2008
This monograph has been modified to include the generic and brand name in many instances.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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