Recommended Topic Related To:

Mintezol

"A unique type of poster placed in exam rooms helped reduce unnecessary antibiotic prescriptions for respiratory infections during flu season. The approach could help reduce costs and extend the usefulness of these drugs.

Antibiotics a"...

Mintezol

Indications
Dosage
How Supplied

INDICATIONS

MINTEZOL (thiabendazole) is indicated for the treatment of: Strongyloidiasis (threadworm) Cutaneous larva migrans (creeping eruption) Visceral larva migrans

Trichinosis: Relief of symptoms and fever and a reduction of eosinophilia have followed the use of MINTEZOL (thiabendazole) during the invasion stage of the disease.

Thiabendazole is usually inappropriate as first line therapy for enterobiasis (pinworm). However, when enterobiasis occurs with any of the conditions listed above, additional therapy is not required for most patients.

MINTEZOL (thiabendazole) should be used only in the following infestations when more specific therapy is not available or cannot be used or when further therapy with a second agent is desirable: Uncinariasis (hookworm: Necator americanus and Ancylostoma duodenale); Trichuriasis (whipworm); Ascariasis (large roundworm).

DOSAGE AND ADMINISTRATION

The recommended maximum daily dose of MINTEZOL (thiabendazole) is 3 grams.

MINTEZOL (thiabendazole) should be given after meals if possible. Tablets MINTEZOL (thiabendazole) should be chewed before swallowing. Dietary restriction, complementary medications and cleansing enemas are not needed.

The usual dosage schedule for all conditions is two doses per day. The dosage is determined by the patient's weight.

A weight-dose chart follows:

Weight Each Dose
g mL
30 lb 0.25 (½ tablet) 2.5 (½ teaspoon)
50 lb 0.5 (1 tablet) 5.0 (1 teaspoon)
75 lb 0.75 (1½ tablets) 7.5 (1½ teaspoons)
100 lb 1.0 (2 tablets) 10.0 (2 teaspoons)
125 lb 1.25 (2½ tablets) 12.5 (2½ teaspoons)
150 lb & over 1.5 (3 tablets) 15.0 (3 teaspoons)

The regimen for each indication follows:

Therapeutic Regimens

Indication Regimen Comments
**STRONGYLOIDIASIS 2 doses per day for 2 successive days. A single dose of 20 mg/lb or 50 mg/kg may be employed as an alternative schedule, but a higher incidence of side effects should be expected.
CUTANEOUS LARVA MIGRANS (Creeping Eruption) 2 doses per day for 2 successive days. If active lesions are still present 2 days after completion of therapy, a second course is recommended.
VISCERAL LARVA MIGRANS 2 doses per day for 7 successive days. Safety and efficacy data on the seven-day treatment course are limited.
**TRICHINOSIS 2 doses per day for 2-4 successive days according to the response of the patient. The optimal dosage for the treatment of trichinosis has not been established.
Other IndicationsIntestinal roundworms (including Ascariasis, Uncinariasis and Trichuriasis) 2 doses per day for 2 successive days. A single dose of 20 mg/lb or 50 mg/kg may be employed as an alternative schedule, but a higher incidence of side effects should be expected.
**Clinical experience with thiabendazole for treatment of each of these conditions in pediatric patients weighing less than 30 lbs has been limited.

HOW SUPPLIED

No. 3331 — MINTEZOL (thiabendazole) Suspension, 500 mg per 5 mL, is white to off-white and is supplied as follows:

NDC 0006-3331-60 in bottles of 120 mL
(6505-00-935-5835, 0.5 g/5 mL, 120 mL).

Storage

Store in a well-closed container at controlled room temperature [15-30°C (59-86°F)]. Protect from freezing.

No. 3332 — MINTEZOL (thiabendazole) Chewable Tablets, 500 mg, are white to off-white, orange-flavored, round, scored, compressed tablets, coded MSD 907 on one side and MINTEZOL (thiabendazole) on the other.

They are supplied as follows:

NDC 0006-0907-36 unit dose packages of 36
(6505-01-226-9909, 500 mg chewable, individually sealed 36's).

Storage

Store in a well-closed container at controlled room temperature [15-30°C (59-86°F)].

MERCK & CO., INC., Whitehouse Station, NJ 08889, USA. Issued June 2003. FDA rev date: 6/11/2003

Last reviewed on RxList: 10/30/2008
This monograph has been modified to include the generic and brand name in many instances.

Indications
Dosage
How Supplied
A A A

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Women's Health

Find out what women really need.