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Details with Side Effects
MINTEZOL (thiabendazole) is indicated for the treatment of: Strongyloidiasis (threadworm) Cutaneous larva migrans (creeping eruption) Visceral larva migrans
Thiabendazole is usually inappropriate as first line therapy for enterobiasis (pinworm). However, when enterobiasis occurs with any of the conditions listed above, additional therapy is not required for most patients.
MINTEZOL (thiabendazole) should be used only in the following infestations when more specific therapy is not available or cannot be used or when further therapy with a second agent is desirable: Uncinariasis (hookworm: Necator americanus and Ancylostoma duodenale); Trichuriasis (whipworm); Ascariasis (large roundworm).
DOSAGE AND ADMINISTRATION
The recommended maximum daily dose of MINTEZOL (thiabendazole) is 3 grams.
MINTEZOL (thiabendazole) should be given after meals if possible. Tablets MINTEZOL (thiabendazole) should be chewed before swallowing. Dietary restriction, complementary medications and cleansing enemas are not needed.
The usual dosage schedule for all conditions is two doses per day. The dosage is determined by the patient's weight.
A weight-dose chart follows:
|30 lb||0.25 (½ tablet)||2.5 (½ teaspoon)|
|50 lb||0.5 (1 tablet)||5.0 (1 teaspoon)|
|75 lb||0.75 (1½ tablets)||7.5 (1½ teaspoons)|
|100 lb||1.0 (2 tablets)||10.0 (2 teaspoons)|
|125 lb||1.25 (2½ tablets)||12.5 (2½ teaspoons)|
|150 lb & over||1.5 (3 tablets)||15.0 (3 teaspoons)|
The regimen for each indication follows:
|**STRONGYLOIDIASIS||2 doses per day for 2 successive days.||A single dose of 20 mg/lb or 50 mg/kg may be employed as an alternative schedule, but a higher incidence of side effects should be expected.|
|CUTANEOUS LARVA MIGRANS (Creeping Eruption)||2 doses per day for 2 successive days.||If active lesions are still present 2 days after completion of therapy, a second course is recommended.|
|VISCERAL LARVA MIGRANS||2 doses per day for 7 successive days.||Safety and efficacy data on the seven-day treatment course are limited.|
|**TRICHINOSIS||2 doses per day for 2-4 successive days according to the response of the patient.||The optimal dosage for the treatment of trichinosis has not been established.|
|Other IndicationsIntestinal roundworms (including Ascariasis, Uncinariasis and Trichuriasis)||2 doses per day for 2 successive days.||A single dose of 20 mg/lb or 50 mg/kg may be employed as an alternative schedule, but a higher incidence of side effects should be expected.|
|**Clinical experience with thiabendazole for treatment of each of these conditions in pediatric patients weighing less than 30 lbs has been limited.|
No. 3331 — MINTEZOL (thiabendazole) Suspension, 500 mg per 5 mL, is white to off-white and is supplied as follows:
NDC 0006-3331-60 in bottles of 120 mL
(6505-00-935-5835, 0.5 g/5 mL, 120 mL).
Store in a well-closed container at controlled room temperature [15-30°C (59-86°F)]. Protect from freezing.
No. 3332 — MINTEZOL (thiabendazole) Chewable Tablets, 500 mg, are white to off-white, orange-flavored, round, scored, compressed tablets, coded MSD 907 on one side and MINTEZOL (thiabendazole) on the other.
They are supplied as follows:
NDC 0006-0907-36 unit dose packages of 36
(6505-01-226-9909, 500 mg chewable, individually sealed 36's).
Store in a well-closed container at controlled room temperature [15-30°C (59-86°F)].
MERCK & CO., INC., Whitehouse Station, NJ 08889, USA. Issued June 2003. FDA rev date: 6/11/2003
Last reviewed on RxList: 10/30/2008
This monograph has been modified to include the generic and brand name in many instances.
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