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(Generic versions may still be available.)
Miradon Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Miradon (anisindione) is an anticoagulant used to prevent and treat venous thrombosis and its extension, the treatment of atrial fibrillation with embolization, the treatment of pulmonary embolism, and as an adjunct in the treatment of coronary occlusion. The brand name of this medication is discontinued, but generic versions may be available. Common side effects include stomach upset or headache as your body adjusts to the medication.
Initial dosage of Miradon Tablets is 300 mg the first day, 200 mg the second day, and 100 mg the third day. Miradon may interact with cholestyramine, chloral hydrate, steroids, alcohol, antacids, antihistamines, barbiturates, carbamazepine, chlordiazepoxide, vitamin K, diuretics, ethchlorvynol, glutethimide, griseofulvin, haloperidol, meprobamate, oral contraceptives, paraldehyde, primidone, ranitidine, rifampin, vitamin C, warfarin, allopurinol, amiodarone, antibiotics, bromelains, chlorpropamide, chymotrypsin, cimetidine, cinchophen, clofibrate, dextran, dextrothyroxine, diazoxide, diflunisal, diuretics, disulfiram, ethacrynic acid, glucagon, hepatotoxic drugs, NSAIDs, indomethacin, flu vaccine, inhalation anesthetics, mefenamic acid, methyldopa, methylphenidate, azole antifungals, MAOIs, oxolinic acid, pentoxifylline, phenyramidol, phenytoin, narcotics, quinidine, quinine, salicylates, thyroid drugs, tolbutamide, triclofos sodium, tolbutamide, dipyridamole, hydrochloroquine, clofibrate, and dextran. Tell your doctor all medications and supplements you use. Miradon is not recommended for use during pregnancy. It may harm a fetus. This drug passes into breast milk. Breastfeeding while using this drug is not recommended.
Our Miradon (anisindione) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Miradon FDA Prescribing Information: Side Effects
Multisystem adverse reactions have been reported, and some may be serious enough to warrant hospital admission. In general, they may be divided into 2 categories: those which involve abnormal bleeding and other effects which do not. Hemorrhage and/or necrosis are among the hazards of treatment with any anticoagulant and are the main serious complications of therapy. For additional discussion of possible hemorrhagic complications following oral anticoagulant therapy see WARNINGS. Although most of the adverse reactions for oral anticoagulant drugs have been reported for warfarin, dicumarol, and phenindione, all the drugs within this class have similar pharmacologic and clinical properties, and require the same degree of caution in monitoring adverse reactions regardless of the drug administered.
Some indanediones (phenindione)have been associated with undesirable reactions which have not been reported with the coumarins and are not counterbalanced by advantages, thus perhaps favoring the use of the coumarin-type anticoagulants. Changing from one chemical type of oral anticoagulant to the other may eliminate an adverse reaction, such as rash or diarrhea. Dermatitis is the only untoward reaction consistently associated with anisindione therapy.
Adverse reactions reported following therapy with either coumarin or indanedione anticoagulants include:nausea, diarrhea, pyrexia, dermatitis or exfoliative dermatitis, urticaria, alopecia, and sore mouth or mouth ulcers.
Side effects which have additionally been reported for coumarin derivatives include:vomit-ing, abdominal cramps, anorexia, priapism, ery-thema and necrosis of the skin and other tissues, manifesting as purple toes and cutaneous gangrene. There is no reason to expect that some or all of these adverse reactions might not occur in patients receiving anisindione.
Additional side effects attributed to the indane-dione anticoagulants include: headache, sore throat, blurred vision, paralysis of accommodation, steatorrhea, hepatitis, jaundice, liver damage, renal tubular necrosis, albuminuria, anuria, myeloid immaturity, agranulocytosis, leukocyte agglutinins, red cell aplasia, atypical mononuclear cells, leukopenia, leukocytosis, anemia, thrombo-cytopenia, and eosinophilia.
Read the entire FDA prescribing information for Miradon (Anisindione)
Additional Miradon Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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