home > drugs a-z list > mirapex (pramipexole) drug center > mirapex (pramipexole) drug - overdosage and contraindications

There is no clinical experience with massive overdosage. One patient, with a 10-year history of schizophrenia, took 11 mg/day of pramipexole for 2 days in a clinical trial to evaluate the effect of pramipexole in schizophrenic patients. No adverse events were reported related to the increased dose. Blood pressure remained stable although pulse rate increased to between 100 and 120 beats/minute. The patient withdrew from the study at the end of week 2 due to lack of efficacy.

There is no known antidote for overdosage of a dopamine agonist. If signs of central nervous system stimulation are present, a phenothiazine or other butyrophenone neuroleptic agent may be indicated; the efficacy of such drugs in reversing the effects of overdosage has not been assessed. Management of overdose may require general supportive measures along with gastric lavage, intravenous fluids, and electrocardiogram monitoring.

MIRAPEX tablets are contraindicated in patients who have demonstrated hypersensitivity to the drug or its ingredients.

Last reviewed on RxList: 6/20/2011
This monograph has been modified to include the generic and brand name in many instances.