Mirapex ER (Pramipexole Dihydrochloride Extended-Release Tablets) Patient Information: Side Effects and Drug Images at RxList

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May 27, 2012

Mirapex ER

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What is Parkinson's disease?

Parkinson's disease is the second most common neurodegenerative disorder and the most common movement disorder. It is characterized by progressive loss of muscle control, which leads to trembling of the limbs and head while at rest, stiffness, slowness, and impaired balance. As symptoms worsen, it may become difficult to walk, talk, and complete simple tasks.

The progression of Parkinson's disease and the degree of impairment vary from individual to individual. Many people with Parkinson's disease live long productive lives, whereas others become disabled much more quickly. Premature death is usually due to complications such as falling-related injuries or pneumonia.

In the United States, about 1 million people are affected by Parkinson's disease and worldwide about 5 million. Most individuals who develop Parkinson's disease are 60 years of age or older. Parkinson's disease occurs in approximately 1% of i...

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MIRAPEX® ER™
(pramipexole dihydrochloride) Extended-Release Tablets

DRUG DESCRIPTION

MIRAPEX ER (pramipexole dihydrochloride extended-release tablets) tablets contain pramipexole, a non-ergot dopamine agonist. The chemical name of pramipexole dihydrochloride is (S)-2-amino-4,5,6,7-tetrahydro-6(propylamino)benzothiazole dihydrochloride monohydrate. Its empirical formula is C₁₀H₁₇N₃S•2HCl•H₂O, and its molecular weight is 302.26.

The structural formula is:

MIRAPEX® ER™ (pramipexole dihydrochloride) Structural Formula Illustration

Pramipexole dihydrochloride is a white to off-white powder substance. Melting occurs in the range of 296°C to 301°C, with decomposition. Pramipexole dihydrochloride is more than 20% soluble in water, about 8% in methanol, about 0.5% in ethanol, and practically insoluble in dichloromethane.

MIRAPEX ER (pramipexole dihydrochloride extended-release tablets) tablets, for oral administration, contain 0.375 mg, 0.75 mg, 1.5 mg, 3 mg, or 4.5 mg of pramipexole dihydrochloride monohydrate. Inactive ingredients are hypromellose, corn starch, carbomer homopolymer, colloidal silicon dioxide, and magnesium stearate.

Last reviewed on RxList: 8/5/2010
This monograph has been modified to include the generic and brand name in many instances.