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Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Mithracin Patient Information including How Should I Take

Who should not take plicamycin (Mithracin)?

Before taking plicamycin, tell your doctor if you have

  • liver disease;
  • kidney disease;
  • bone marrow problems; or
  • a bleeding disorder.

You may not be able to take plicamycin, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Plicamycin is in the FDA pregnancy category X. This means that plicamycin is known to cause birth defects in an unborn baby. Plicamycin may also affect egg production in women and sperm production in men. Do not take plicamycin if you are pregnant or could become pregnant during treatment. Contraceptive measures are recommended during treatment with plicamycin.

It is not known whether plicamycin passes into breast milk. Do not take plicamycin without first talking to your doctor if you are breast feeding a baby.

How should I take plicamycin (Mithracin)?

Plicamycin should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Your doctor will determine the correct amount and frequency of treatment with plicamycin depending upon the type of cancer being treated and other factors. Talk to your doctor if you have any questions or concerns regarding the treatment schedule.

Your doctor will probably want you to have regularly scheduled blood tests and other medical evaluations during treatment with plicamycin to monitor progress and side effects.

Your healthcare provider will store cladribine as directed by the manufacturer. If you are storing cladribine, follow the directions provided by your healthcare provider.

Side Effects Centers

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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