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MOBAN (molindone hydrochloride tablets) has a pharmacological profile in laboratory animals which predominantly resembles that of other antipsychotic agents causing reduction of spontaneous locomotion and aggressiveness, suppression of a conditioned response and antagonism of the bizarre stereotyped behavior and hyperactivity induced by amphetamines. In addition, MOBAN (molindone hydrochloride tablets) antagonizes the depression caused by the tranquilizing agent tetrabenazine.
In human clinical studies an antipsychotic effect is achieved in the absence of muscle relaxing or incoordinating effects. Based on EEG studies, MOBAN (molindone hydrochloride tablets) exerts its effect on the ascending reticular activating system.
Human metabolic studies show MOBAN (molindone hydrochloride tablets) to be rapidly absorbed and metabolized when given orally. Unmetabolized drug reached a peak blood level at 1.5 hours. Pharmacological effect from a single oral dose persists for 24-36 hours. There are 36 recognized metabolites with less than 23% unmetabolized MOBAN (molindone hydrochloride tablets) being excreted in urine and feces.
Last reviewed on RxList: 1/13/2011
This monograph has been modified to include the generic and brand name in many instances.
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