"The US Food and Drug Administration (FDA) announced today that its review of two patients who died after receiving intramuscular injections of the schizophrenia drug olanzapine pamoate (Zyprexa Relprevv, Eli Lilly) is inconclusive, altho"...
Symptomatic, supportive therapy should be the rule.
Gastric lavage is indicated for the reduction of absorption of MOBAN (molindone hydrochloride tablets) which is freely soluble in water.
Since the adsorption of MOBAN (molindone hydrochloride tablets) by activated charcoal has not been determined, the use of this antidote must be considered of theoretical value.
Emesis in a comatose patient is contraindicated. Additionally, while the emetic effect of apomorphine is blocked by MOBAN (molindone hydrochloride tablets) in animals, this blocking effect has not been determined in humans.
A significant increase in the rate of removal of unmetabolized MOBAN (molindone hydrochloride tablets) from the body by forced diuresis, peritoneal or renal dialysis would not be expected. (Only 2% of a single ingested dose of MOBAN (molindone hydrochloride tablets) is excreted unmetabolized in the urine). However, poor response of the patient may justify use of these procedures.
While the use of laxatives or enemas might be based on general principles, the amount of unmetabolized MOBAN (molindone hydrochloride tablets) in feces is less than 1%. Extrapyramidal symptoms have responded to the use of Diphenhydramine (Benadryl®), Amantadine HCl (Symmetrel®) and the synthetic anticholinergic antiparkinson agents, (i.e., Artane®, Cogentin®, Akineton®).
MOBAN (molindone hydrochloride tablets) is contraindicated in severe central nervous system depression (alcohol, barbiturates, narcotics, etc.) or comatose states, and in patients with known hypersensitivity to the drug.
Last reviewed on RxList: 1/13/2011
This monograph has been modified to include the generic and brand name in many instances.
Additional Moban Information
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