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MODURETIC (amiloride HCl-Hydrochlorothiazide) combines the potassium-conserving action of amiloride HCl with the natriuretic action of hydrochlorothiazide.
Amiloride HCl is designated chemically as 3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinecarboxamide monohydrochloride, dihydrate and has a molecular weight of 302.12. Its empirical formula is C6H8ClN7OH02H2O and its structural formula is:
Hydrochlorothiazide is designated chemically as 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C7H8ClN3O4S2 and its structural formula is:
It is a white, or practically white, crystalline powder with a molecular weight of 297.74, which is slightly soluble in water, but freely soluble in sodium hydroxide solution.
MODURETIC (amiloride and hydrochlorothiazide) is available for oral use as tablets containing 5 mg of anhydrous amiloride HCl and 50 mg of hydrochlorothiazide. Each tablet contains the following inactive ingredients: calcium phosphate, FD&C Yellow 6, guar gum, lactose, magnesium stearate and starch.
What are the possible side effects of hydrochlorothiazide and amiloride (Moduretic 5-50)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have a serious side effect such as:
- eye pain, vision problems;
- numbness or tingly feeling;
- muscle pain or weakness;
- slow, fast, or uneven heartbeat;
- feeling drowsy, restless, or light-headed;
- urinating less than usual or not at all;
- dry mouth, increased thirst, tiredness,...
What are the precautions when taking amiloride and hydrochlorothiazide (Moduretic)?
See also Warning section.
Before taking this product, tell your doctor or pharmacist if you are allergic to amiloride or hydrochlorothiazide; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: untreated salt/mineral imbalance (such as high potassium, low sodium level), kidney disease, liver disease, diabetes, loss of too much body water (dehydration), lupus, gout, high levels of fats in the blood (cholesterol/triglycerides).
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs,...
Last reviewed on RxList: 4/24/2009
This monograph has been modified to include the generic and brand name in many instances.
Additional Moduretic Information
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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