July 23, 2016
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"The U.S. Food and Drug Administration today approved Dotarem (gadoterate meglumine) for use in magnetic resonance imaging (MRI) of the brain, spine and associated tissues of patients ages 2 years and older.

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Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)



Although anaphylactic reactions have not been reported with the Mono-Vacc®Test (O.T.), this remote possibility should be considered.



Epinephrine Injection (1:1000) should be available in the rare event an anaphylactic or acute hypersensitivity reaction occurs.

Do not apply the Mono-Vacc® Test (O.T.) to acneiform skin, hairy areas or where there is inadequate subcutaneous tissue.

Although repeated testing of uninfected individuals does not sensitize to tuberculin, it may have a "booster" effect in persons with low levels of sensitivity to homologous or heterologous mycobacterial antigens.

Testing should be done with caution in persons with active tuberculosis, however, activation of quiescent lesions is rare.

Drug Interactions

The administration of adrenal corticosteroids or immunosuppressive drugs may decrease the intensity of or prevent a tuberculin reaction. Tuberculin sensitivity may decrease or disappear temporarily as a result of febrile illness; measles and other exanthemas; live virus vaccination; sarcoidosis and miliary or pulmonary tuberculosis.


Reproductive Studies — Category C: Animal reproduction studies have not been conducted with Tuberculin, Old Mono-Vacc ®Test (O.T.). It is also not known whether Tuberculin, Old can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. Tuberculin, Old should be given to a pregnant woman only if clearly needed.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 12/8/2004


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