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Monodox

Last reviewed on RxList: 4/13/2017
Monodox Side Effects Center

Last reviewed on RxList 10/28/2016

Monodox (doxycycline monohydrate) is a tetracycline antibiotic used to treat many different bacterial infections, such as urinary tract infections, acne, gonorrhea, and chlamydia, periodontitis (gum disease), and others. Monodox is also used to treat blemishes, bumps, and acne-like lesions caused by rosacea (but will not treat facial redness caused by rosacea). Monodox is available in generic form. Common side effects of Monodox include:

  • stomach upset,
  • diarrhea,
  • nausea,
  • vomiting,
  • skin rash or itching, or
  • vaginal itching or discharge.

Tell your doctor if you have serious side effects of Monodox including:

  • sunburn (sun sensitivity),
  • painful or difficult swallowing, or
  • changes in the amount of urine.

The usual adult dose of Monodox is 200 mg on the first day of treatment (100 mg every 12 hours or 50 mg every 6 hours), and a maintenance dose of 100 mg/day. The maintenance dose may be taken as a single dose or as 50 mg every 12 hours. The recommended dosage for pediatric patients weighing 100 pounds or less is 2 mg/lb of body weight divided into two doses on the first day of treatment, followed by 1 mg/lb of body weight given as a single daily dose or divided into two doses, on subsequent days. Monodox may interact with cholesterol-lowering medications, isotretinoin, tretinoin, antacids, bismuth subsalicylate (e.g., Pepto-Bismol), blood thinners, penicillin antibiotics, or minerals such as iron, zinc, calcium, magnesium, and over-the-counter vitamin supplements. Tell your doctor all medications and supplements you are taking. Monodox is not recommended for use during pregnancy. It may harm a fetus. Use reliable forms of birth control while taking this medication. This drug passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breastfeeding.

Our Monodox (doxycycline monohydrate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Monodox Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • severe headache, dizziness, blurred vision;
  • fever, chills, body aches, flu symptoms, swollen glands, rash or itching, joint pain, or general ill feeling;
  • urinating less than usual or not at all;
  • diarrhea that is watery or bloody
  • pale or yellowed skin, dark colored urine, fever, confusion or weakness;
  • severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
  • loss of appetite, jaundice (yellowing of the skin or eyes); or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • mild nausea, mild diarrhea;
  • upset stomach;
  • mild skin rash or itching; or
  • vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Monodox (Doxycycline)

Monodox Professional Information

SIDE EFFECTS

Due to oral doxycycline’s virtually complete absorption, side effects to the lower bowel, particularly diarrhea, have been infrequent. The following adverse reactions have been observed in patients receiving tetracyclines.

Gastrointestinal

Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, and inflammatory lesions (with monilial overgrowth) in the anogenital region, and pancreatitis. Hepatotoxicity has been reported. These reactions have been caused by both the oral and parenteral administration of tetracyclines. Rare instances of esophagitis and esophageal ulcerations have been reported in patients receiving capsule and tablet forms of drugs in the tetracycline class. Most of these patients took medications immediately before going to bed. (See DOSAGE AND ADMINISTRATION.)

Skin

Maculopapular and erythematous rashes, Stevens-Johnson syndrome, toxic epidermal necrolysis, and erythema multiforme have been reported. Exfoliative dermatitis has been reported but is uncommon. Photosensitivity is discussed above. (See WARNINGS.)

Renal Toxicity

Rise in BUN has been reported and is apparently dose related. (See WARNINGS.)

Hypersensitivity Reactions

Urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, and exacerbation of systemic lupus erythematosus.

Blood

Hemolytic anemia, thrombocytopenia, neutropenia, and eosinophilia have been reported with tetracyclines.

Other

Intracranial hypertension (IH, pseudotumor cerebri) has been associated with the use of tetracyclines. (See PRECAUTIONS - General.)

When given over prolonged periods, tetracyclines have been reported to produce brown-black microscopic discoloration of the thyroid gland. No abnormalities of thyroid function are known to occur.

Read the entire FDA prescribing information for Monodox (Doxycycline)

Related Resources for Monodox

Read the Monodox User Reviews »

© Monodox Patient Information is supplied by Cerner Multum, Inc. and Monodox Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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