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Monopril

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Monopril

MONOPRIL®
(fosinopril sodium) Tablets

Monopril

USE IN PREGNANCY

When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, MONOPRIL (fosinopril sodium) should be discontinued as soon as possible. See WARNINGS: Fetal/Neonatal Morbidity and Mortality.

DRUG DESCRIPTION

MONOPRIL® (fosinopril sodium tablets) is the sodium salt of fosinopril, the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, fosinoprilat. It contains a phosphinate group capable of specific binding to the active site of angiotensin-converting enzyme. Fosinopril sodium is designated chemically as: L-proline, 4-cyclohexyl-1-[[[2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-, sodium salt, trans-.

Fosinopril sodium is a white to off-white crystalline powder. It is soluble in water (100 mg/mL), methanol, and ethanol and slightly soluble in hexane.

Its structural formula is:

MONOPRIL®
  (fosinopril sodium) Structural Formula Illustration

Its empirical formula is C30H45NNaO7P, and its molecular weight is 585.65.

MONOPRIL (fosinopril sodium) is available for oral administration as 10 mg, 20 mg, and 40 mg tablets. Inactive ingredients include: lactose, microcrystalline cellulose, crospovidone, povidone, and sodium stearyl fumarate.

What are the possible side effects of fosinopril (Monopril)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • feeling light-headed, fainting;
  • urinating less than usual, or not at all;
  • fever, chills, body aches, flu symptoms;
  • severe blistering, peeling, and red skin rash;
  • pale skin, easy bruising or bleeding, unusual weakness;
  • pounding or uneven heartbeats;
  • slow heart rate, weak...

Read All Potential Side Effects and See Pictures of Monopril »

What are the precautions when taking fosinopril sodium (Monopril)?

Before taking fosinopril, tell your doctor or pharmacist if you are allergic to it; or to other ACE inhibitors (such as benazepril); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of an allergic reaction which included swelling of the face/lips/tongue/throat (angioedema), blood filtering procedures (such as LDL apheresis, dialysis), high level of potassium in the blood, collagen vascular disease (such as lupus, scleroderma).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are...

Read All Potential Precautions of Monopril »

Last reviewed on RxList: 6/30/2009
This monograph has been modified to include the generic and brand name in many instances.

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Monopril - User Reviews

Monopril User Reviews

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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