"Troy Brown, RN
Medscape Medical News
Clostridium difficile caused nearly half a million infections and was associated with about 29,000 deaths in 2011, according to new data released today by the Centers for Disease Control "...
(difenoxin hydrochloride and atropine sulfate) Tablet
Each five-sided dye free MOTOFEN (difenoxin and atropine) ® tablet contains:
Difenoxin (as the hydrochloride) . . .. . . . . . . . . . . . . . . . . . . .1.0 mg
Atropine Sulfate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .0.025 mg
Difenoxin hydrochloride, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylic acid monohydrochloride, is an orally administered antidiarrheal agent which is chemically related to the narcotic meperidine.
The structural formula is:
Atropine sulfate is present to discourage deliberate overdosage.
Atropine sulfate, an anticholinergic, is endo (±)-α-(hydroxymethyl) benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1] oct-3-yl ester sulfate (2:1) (salt) monohydrate and has the following structural formula:
What are the precautions when taking difenoxin and atropine (Motofen)?
Before taking difenoxin with atropine, tell your doctor or pharmacist if you are allergic to either drug; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: liver disease (e.g., obstructive jaundice, cirrhosis), diarrhea caused by certain types of infections (Clostridium difficile-associated diarrhea following recent antibiotic therapy, bacterial infection of the gut caused by E. coli, Salmonella, Shigella).
Before using this medication, tell your doctor or pharmacist your medical history, especially...
Last reviewed on RxList: 5/12/2009
This monograph has been modified to include the generic and brand name in many instances.
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