Motofen (Difenoxin and Atropine) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Motofen

Diarrhea »

Diarrhea facts

Diarrhea is an increase in the frequency of bowel movements, an increase in the looseness of stool or both.
Diarrhea is caused by increased secretion of fluid into the intestine, reduced absorption of fluid from the intestine or rapid passage of stool through the intestine.
Diarrhea can be defined absolutely or relatively. Absolute diarrhea is defined as more than five bowel movements a day or liquid stools. Relative diarrhea is defined as an increase in the number of bowel movements per day or an increase in the looseness of stools compared with an individual's usual bowel habit.
Diarrhea may be either acute or chronic, and each has different causes and treatments.
Complications of diarrhea include dehydration, electrolytes (mineral) abnormalities, and irritation of the anus.
Dehydration can be treated with oral ...

Read the Diarrhea article »

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MOTOFEN
(difenoxin hydrochloride and atropine sulfate) Tablet

DRUG DESCRIPTION

Each five-sided dye free MOTOFEN (difenoxin and atropine) ® tablet contains:

Difenoxin (as the hydrochloride) . . .. . . . . . . . . . . . . . . . . . . .1.0 mg

Atropine Sulfate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .0.025 mg

Difenoxin hydrochloride, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylic acid monohydrochloride, is an orally administered antidiarrheal agent which is chemically related to the narcotic meperidine.

The structural formula is:

Difenoxin Hydrochloride

Atropine sulfate is present to discourage deliberate overdosage.

Atropine sulfate, an anticholinergic, is endo (±)-α-(hydroxymethyl) benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1] oct-3-yl ester sulfate (2:1) (salt) monohydrate and has the following structural formula:

Atropine sulfate Structural Formula Illustration

Inactive ingredients: calcium stearate, cellulose, lactose, corn starch.

What are the precautions when taking difenoxin and atropine (Motofen)?

Before taking difenoxin with atropine, tell your doctor or pharmacist if you are allergic to either drug; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: liver disease (e.g., obstructive jaundice, cirrhosis), diarrhea caused by certain types of infections (Clostridium difficile-associated diarrhea following recent antibiotic therapy, bacterial infection of the gut caused by E. coli, Salmonella, Shigella).

Before using this medication, tell your doctor or pharmacist your medical history, especially...

Read All Potential Precautions of Motofen »

Last reviewed on RxList: 5/12/2009
This monograph has been modified to include the generic and brand name in many instances.