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MOTOFEN
(difenoxin hydrochloride and atropine sulfate) Tablet
Each five-sided dye free MOTOFEN (difenoxin and atropine) ® tablet contains:
Difenoxin (as the hydrochloride) . . .. . . . . . . . . . . . . . . . . . . .1.0 mg
Atropine Sulfate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .0.025 mg
Difenoxin hydrochloride, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylic acid monohydrochloride, is an orally administered antidiarrheal agent which is chemically related to the narcotic meperidine.
The structural formula is:
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Atropine sulfate is present to discourage deliberate overdosage.
Atropine sulfate, an anticholinergic, is endo (±)-α-(hydroxymethyl) benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1] oct-3-yl ester sulfate (2:1) (salt) monohydrate and has the following structural formula:
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Inactive ingredients: calcium stearate, cellulose, lactose, corn starch.
Last reviewed on RxList: 5/12/2009
This monograph has been modified to include the generic and brand name in many instances.
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