Mozobil (Plerixafor Injection) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 10, 2012

Mozobil

Non-Hodgkin's Lymphoma »

Non-Hodgkin's lymphoma facts

NHL is a cancer that originates in the lymphatic system.
About 66,000 patients are diagnosed yearly, and approximately 18,000 patients die of NHL yearly in the U.S.
There are several subtypes of NHL, each requiring different treatments.
Symptoms include swollen lymph nodes, weight loss, fever, and night sweats.
NHL is staged on a 1-4 scale with A (no associated symptoms like fever, weight loss, or night sweats) and B subtypes.
Staging the cancer is important to determine treatment and predict the outcome of treatment.
Depending on the stage and type of NHL, treatment can include chemotherapy, biological therapy, stem cell transplant, and/or radiation therapy.

What is non-Hodgkin's lymphoma?

Non-Hodgkin's lymphoma is a type of cancer that originates in the lymphatic system. It is estimated to be the sixth most common cancer in the Unite...

Read the Non-Hodgkin's Lymphoma article »

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Mozobil

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MOZOBIL
(plerixafor) Injection, Solution for Subcutaneous Use

DRUG DESCRIPTION

Mozobil (plerixafor injection) is a sterile, preservative-free, clear, colorless to pale yellow, isotonic solution for subcutaneous injection. Each mL of the sterile solution contains 20 mg of plerixafor. Each single-use vial is filled to deliver 1.2 mL of the sterile solution that contains 24 mg of plerixafor and 5.9 mg of sodium chloride in Water for Injection adjusted to a pH of 6.0 to 7.5 with hydrochloric acid and with sodium hydroxide, if required.

Plerixafor is a hematopoietic stem cell mobilizer with a chemical name 1, l'-[l,4-phenylenebis (methylene)]-bis-l,4,8,11- tetraazacyclotetradecane. It has the molecular formula C₂₈H₅₄N₈. The molecular weight of plerixafor is 502.79 g/mol. The structural formula is provided in Figure 1.

Figure 1: Structural Formula

Mozobil (plerixafor) Structural Formula Illustration

Plerixafor is a white to off-white crystalline solid. It is hygroscopic. Plerixafor has a typical melting point of 131.5 °C. The partition coefficient of plerixafor between 1 -octanol and pH 7 aqueous buffer is < 0.1.

What are the possible side effects of plerixafor (Mozobil)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as: