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MS-Contin

Last reviewed on RxList: 5/31/2017
MS-Contin Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 5/31/2017

MS Contin (morphine sulfate) is a narcotic pain reliever prescribed to treat moderate to severe pain. MS Contin is the generic form of morphine. Common side effects of MS Contin are:

  • constipation,
  • diarrhea,
  • lightheadedness,
  • headache,
  • dizziness,
  • spinning sensation,
  • drowsiness,
  • nausea,
  • vomiting,
  • stomach pain,
  • loss of appetite,
  • weight loss,
  • sweating,
  • flushing (warmth, redness, or tingly feeling),
  • memory problems,
  • sleep problems (insomnia or strange dreams),
  • depression,
  • anxiety,
  • restlessness, and
  • euphoria.

 Tell your doctor if you experience serious side effects of MS Contin including:

  • mental/mood changes (such as agitation, confusion, hallucinations),
  • severe stomach/abdominal pain, or
  • difficulty urinating.

Initiate treatment with MS Contin with a dose of 15 mg tablets orally every 8 or 12 hours. Drug interactions and warnings include: avoiding concomitant use of other central nervous system depressants including sedatives or hypnotics, general anesthetics, phenothiazines, tranquilizers, and alcohol as these may produce additive depressant effects. MS Contin (morphine sulfate) should be used in pregnant women only if the need MS Contin (morphine sulfate) clearly outweighs the potential risk to the fetus. Ordinarily, nursing should not be undertaken while a patient is receiving MS Contin (morphine sulfate) since morphine may be excreted in the milk. This medication may cause withdrawal reactions.

Our MS Contin (morphine sulfate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

MS-Contin Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • shallow breathing, slow heartbeat;
  • stiff muscles, seizure (convulsions);
  • cold, clammy skin;
  • confusion, unusual thoughts or behavior;
  • severe weakness, feeling like you might pass out;
  • trouble swallowing;
  • urinating less than usual or not at all;
  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin.

Less serious side effects may include:

  • weight loss;
  • constipation, diarrhea;
  • nausea, vomiting, stomach pain, loss of appetite;
  • flushing (warmth, redness, or tingly feeling);
  • headache, dizziness, spinning sensation;
  • memory problems; or
  • sleep problems (insomnia), strange dreams.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for MS-Contin (Morphine Sulfate Controlled-Release)

MS-Contin Professional Information

SIDE EFFECTS

The following serious adverse reactions are described elsewhere in the labeling:

Clinical Trial Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

MS CONTIN may increase the risk of serious adverse reactions such as those observed with other opioid analgesics, including respiratory depression, apnea, respiratory arrest, circulatory depression, hypotension, or shock [see OVERDOSAGE].

Most Frequently Observed Reactions

In clinical trials, the most common adverse reactions with MS CONTIN were constipation, dizziness, sedation, nausea, vomiting, sweating, dysphoria, and euphoric mood.

Some of these effects seem to be more prominent in ambulatory patients and in those not experiencing severe pain.

Less Frequently Observed Reactions

Cardiovascular disorders: tachycardia, bradycardia, palpitations

Eye disorders: visual impairment, vision blurred, diplopia, miosis

Gastrointestinal disorders: dry mouth, diarrhea, abdominal pain, constipation, dyspepsia

General disorders and administration site conditions: chills, feeling abnormal, edema, edema peripheral, weakness

Hepatobiliary disorders: biliary colic

Metabolism and nutrition disorders: anorexia

Musculoskeletal and connective tissue disorders: muscle rigidity, muscle twitching

Nervous system disorders: presyncope, syncope, headache, tremor, uncoordinated muscle movements, convulsion, intracranial pressure increased, taste alteration, paresthesia, nystagmus

Psychiatric disorders: agitation, mood altered, anxiety, depression, abnormal dreams, hallucination, disorientation, insomnia

Renal and urinary disorders: urinary retention, urinary hesitation, antidiuretic effects

Reproductive system and breast disorders: reduced libido and/or potency

Respiratory, thoracic and mediastinal disorders: laryngospasm

Skin and subcutaneous tissue disorders: pruritus, urticaria, rash

Vascular disorders: flushing, hypotension, hypertension

Post-Marketing Experience

The following adverse reactions have been identified during postapproval use of MS CONTIN: amenorrhea, asthenia, bronchospasm, confusional state, drug hypersensitivity, fatigue, hyperalgesia, hypertonia, ileus, increased hepatic enzymes, intestinal obstruction, lethargy, malaise, pulmonary edema, thinking disturbances, somnolence, and vertigo.

Anaphylaxis has been reported with ingredients contained in MS CONTIN. Advise patients how to recognize such a reaction and when to seek medical attention.

Read the entire FDA prescribing information for MS-Contin (Morphine Sulfate Controlled-Release)

Related Resources for MS-Contin

Read the MS-Contin User Reviews »

© MS-Contin Patient Information is supplied by Cerner Multum, Inc. and MS-Contin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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