Charles Patrick Davis, MD, PhD
Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.
Mary D. Nettleman, MD, MS, MACP
Mary D. Nettleman, MD, MS, MACP is the Chair of the Department of Medicine at Michigan State University. She is a graduate of Vanderbilt Medical School, and completed her residency in Internal Medicine and a fellowship in Infectious Diseases at Indiana University.
In this Article
- Mucormycosis (zygomycosis) facts
- What is mucormycosis?
- What causes mucormycosis?
- What are risk factors for mucormycosis?
- What are symptoms and signs of mucormycosis?
- How is mucormycosis diagnosed?
- What is the treatment of mucormycosis?
- What are complications of mucormycosis?
- What is the prognosis of mucormycosis?
- Can mucormycosis be prevented?
- What research is being done on mucormycosis?
- Where can people find more information on mucormycosis?
- Find a local Doctor in your town
What is the treatment of mucormycosis?
Treatments of mucormycosis need to be fast and aggressive. The need for speed is because by the time even the presumptive diagnosis is made, often the patient has suffered significant tissue damage that cannot be reversed. Most patients will require both surgical and medical treatments. Most infectious-disease experts say that without aggressive surgical debridement of the infected area, the patient is likely to die. Medications play an important role. Two main goals are sought at the same time: antifungal medications to slow or halt fungal spread and medications to treat any debilitating underlying diseases. Amphotericin B (initially intravenous) is the usual drug of choice for antifungal treatment. Patients with underlying diseases like diabetes need their diabetes optimally controlled. Patients normally on steroids or undergoing treatment with deferoxamine (Desferal; used to remove excess iron in the body) are likely to have these medications stopped because they can increase the survival of fungi in the body. Patients may need additional surgeries and usually need antifungal therapy for an extended time period (weeks to months) depending on the severity of the disease. Consultation with an infectious-disease expert is advised.
Learn more about: Desferal
What are complications of mucormycosis?
The complications of mucormycosis are serious and are related to the body area initially infected but also can occur in other body regions because the fungi often spreads to the organs or tissues that physically contact or are near the originally infected area. In addition, because surgical debridement is almost uniformly needed, some normal tissue may be destroyed because the surgeon must remove all tissue that is dead or dying. Unfortunately, that means the surgeon may have to remove some normal tissue to insure all of the fungi are removed. An example is infection of the eye orbit; often the whole eye must be removed. Consequently, serious complications such as blindness, meningitis, brain abscesses, osteomyelitis, pulmonary hemorrhages, gastrointestinal hemorrhages, cavitary lesions in organs and eventually secondary bacterial infections, sepsis, and death may occur.
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