home > drugs a-z list > multihance (gadobenate dimeglumine injection) drug center > multihance (gadobenate dimeglumine injection) drug - medication guide and patient information

Nephrogenic Systemic Fibrosis

Instruct patients to inform their physician if they:

• have a history of kidney and/or liver disease, or
• have recently received a GBCA.

GBCAs increase the risk for NSF among patients with impaired elimination of the drugs. To counsel patients at risk for NSF:

• Describe the clinical manifestations of NSF
• Describe procedures to screen for the detection of renal impairment

Instruct the patients to contact their physician if they develop signs or symptoms of NSF following MultiHance (gadobenate dimeglumine injection) administration, such as burning, itching, swelling, scaling, hardening and tightening of the skin; red or dark patches on the skin; stiffness in joints with trouble moving, bending or straightening the arms, hands, legs or feet; pain in the hip bones or ribs; or muscle weakness.

Common Adverse Reactions

Inform patients that they may experience:

• reactions along the venous injection site, such as mild and transient burning or pain or feeling of warmth or coldness at the injection site
• side effects of feeling hot, nausea, and headache.

General Precautions

Instruct patients scheduled to receive MultiHance (gadobenate dimeglumine injection) to inform their physician if they:

• are pregnant or breast feeding
• have a history of renal disease, heart disease, seizure, asthma or allergic respiratory diseases
• are taking any medications
• have any allergies to any of the ingredients of MultiHance (gadobenate dimeglumine injection) .

Last reviewed on RxList: 2/10/2011
This monograph has been modified to include the generic and brand name in many instances.