Multihance (Gadobenate Dimeglumine Injection) Patient Information: Side Effects and Drug Images at RxList

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May 27, 2012

Multihance

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MultiHance
(gadobenate dimeglumine) Injection

WARNING

NEPHROGENIC SYSTEMIC FIBROSIS

Gadolinium-based contrast agents (GBCAs) increase the risk for NSF among patients with impaired elimination of the drugs. Avoid use of GBCAs in these patients unless the diagnostic information is essential and not available with non-contrasted MRI or other modalities. NSF may result in fatal or debilitating systemic fibrosis affecting the skin, muscle and internal organs.

The risk for NSF appears highest among patients with:
- chronic, severe kidney disease (GFR < 30 mL/min/1.73m²), or
- acute kidney injury.
Screen patients for acute kidney injury and other conditions that may reduce renal function. For patients at risk for chronically reduced renal function (e.g. age > 60 years, hypertension or diabetes), estimate the glomerular filtration rate (GFR) through laboratory testing.
For patients at highest risk for NSF, do not exceed the recommended MultiHance (gadobenate dimeglumine injection) dose and allow a sufficient period of time for elimination of the drug from the body prior to re-administration [see WARNINGS AND PRECAUTIONS]

DRUG DESCRIPTION

MultiHance (gadobenate dimeglumine injection) injection is supplied as a sterile, nonpyrogenic, clear, colorless aqueous solution intended for intravenous use only. Each mL of MultiHance contains 529 mg gadobenate dimeglumine and water for injection. MultiHance contains no preservatives.

Gadobenate dimeglumine is chemically designated as (4RS)-[4-carboxy-5,8,11-tris(carboxymethyl)- 1-phenyl-2oxa-5,8,11-triazatridecan-13-oato(5-)] gadolinate(2-) dihydrogen compound with 1-deoxy-1-(methylamino)-Dglucitol (1:2) with a molecular weight of 1058.2 and an empirical formula of C₂₂H₂₈GdN₃O₁₁ • 2C₇H₁₇NO₅. The structural formula is as follows:

MultiHance (gadobenate dimeglumine) Structural Formula Illustration

MultiHance (gadobenate dimeglumine injection) has a pH of 6.5-7.5. Pertinent physicochemical parameters are provided below:

Osmolality	1.970 osmol/kg @ 37°C
Viscosity	5.3 mPas @ 37°C
Density	1.220 g/mL @ 20°C

MultiHance (gadobenate dimeglumine injection) has an osmolality 6.9 times that of plasma (285 mOsmol/kg water) and is hypertonic under conditions of use.

Last reviewed on RxList: 2/10/2011
This monograph has been modified to include the generic and brand name in many instances.