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Mumps Skin Test Antigen

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Mumps Skin Test Antigen

CLINICAL PHARMACOLOGY

Information is available concerning the pharmacologic mode of action of skin test antigens.1 Skin testing is a widely employed and readily available method ofclinically assessing the cellular immune response. A positive skin-test reaction indicates previous antigenic exposure, T-cell competence, an intact inflammatory response, and is an assessment ofthe cellular integrity ofthe immune response.

Skin testing with MSTA detects delayed-hypersensitivity.2 Since most of the population (except for the very young) have had contact or infection with mumps virus,m³they usually demonstrate a delayed-hypersensitivity reaction to MSTA if an adequate cellular immune system exists.4

A single masked placebo-controlled study involving 90 cancer subjects was performed using MSTA, Tetanus Toxoid Fluid, Mixed Respiratory Vaccine, Dermatophyton O. staphage Iysate and PPD (Tubersol®). The injection sites were read at 48 and 72 hours. The number of positive reactors to MSTA was greater than the number of positive subjects receiving the other antigens. None of the patients experienced any sloughing, necrosis, abscess formation, or painful Iymphadenopathy as a result of the MSTA skin test. This study demonstrated that MSTA evoked a positive delayed-hypersensitivity (DH) reaction in immunocompetent individuals. The frequency of reactions in subjects with an impaired immune system was reduced. The sensitivity of MSTA has been demonstrated by the fact that: 1) in all instances when any of the other test antigens were positive, MSTA was also positive; and 2) several subjects showed a DH reaction to MSTA but did not show a DH reaction to the other antigens.2

REFERENCES

1. Holborow EJ, et al. Immunology in Medicine. Second Edition, pp 19 and 121. Grune & Stratton, 1983

2. Unpublished data available from Aventis Pasteur Inc.

3. Petersdorf RG. Mumps. in Harrison's Principles of Internal Medicine, Ed. 7 (edited by M.M. Wintrobe, G.W. Thorn, R.D. Adams, E.Braunwald, K.J. Isselbacher, and R.G. Petersdorf) p 985. New York: McGraw-Hill Book Company, 1974

4. Dempster G. Mumps in Textbook of Virology, Ed. 5 (edited by A.J. Rhodes and C.E. Van Rooyen) p 461 Baltimore: The Williams & Wilkins Co., 1968

Last reviewed on RxList: 12/19/2008
This monograph has been modified to include the generic and brand name in many instances.

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