Mustargen (Mechlorethamine HCl) Drug Information: Overdosage and Contraindications

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May 27, 2012

Mustargen

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Mustargen

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OVERDOSE

With total doses exceeding 0.4 mg/kg of body weight for a single course, severe leukopenia, anemia, thrombocytopenia and a hemorrhagic diathesis with subsequent delayed bleeding may develop. Death may follow. The only treatment in instances of excessive dosage appears to be repeated blood product transfusions, antibiotic treatment of complicating infections and general supportive measures.

The intravenous LD₅₀ of MUSTARGEN (mechlorethamine hcl) is 2 mg/kg and 1.6 mg/kg in the mouse and rat, respectively. The oral LD₅₀ for mechlorethamine hydrochloride is 20 mg/kg and 10 mg/kg in the mouse and rat, respectively.

CONTRAINDICATIONS

The use of MUSTARGEN (mechlorethamine hcl) is contraindicated in the presence of known infectious diseases and in patients who have had previous anaphylactic reactions to MUSTARGEN (mechlorethamine hcl) .

Last reviewed on RxList: 5/21/2009
This monograph has been modified to include the generic and brand name in many instances.