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Myambutol Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
- loss of appetite,
- upset stomach,
- abdominal pain,
- worsening gout, or
- joint pain.
Tell your doctor if you have unlikely but serious side effects of Myambutol including:
- vision changes (such as blurred or decreased vision, color blindness),
- symptoms of liver disease (such as persistent nausea or vomiting, unusual tiredness or weakness, severe stomach or abdominal pain, yellowing eyes or skin, dark urine),
- numbness or tingling of arms or legs, or
- toe or joint pain.
The initial dose of Myambutol is 15 mg/kg (7 mg/lb) of body weight, taken as a single oral dose once every 24 hours. Do not take antacids containing aluminum within several hours of taking a dose of Myambutol, as this will decrease the amount of the drug that is absorbed by the body. Other drugs may interact with Myambutol. Tell your doctor all prescription or over-the-counter medicines and supplements you use. During pregnancy, Myambutol should be used only when prescribed. This medication passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breastfeeding. If you have HIV disease, do not breastfeed because breast milk can transmit HIV.
Our Myambutol (ethambutol) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Myambutol in Detail - Patient Information: Side Effects
If you experience any of the following serious side effects, stop taking ethambutol and seek emergency medical attention or contact your doctor immediately:
- an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
- vision changes (e.g., blurring, red-green color blindness);
- a rash;
- numbness or tingling in your fingers, toes, hands, or feet;
- confusion, disorientation, or hallucinations; or
Other, less serious side effects may be more likely to occur. Continue to take ethambutol and talk to your doctor if you experience
- stomach upset, nausea, vomiting, abdominal pain, or decreased appetite;
- mild dizziness;
- worsening gout; or
- joint pain.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Myambutol (Ethambutol)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Myambutol Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: vision changes (such as blurred/decreased vision, color blindness), symptoms of liver disease (such as persistent nausea/vomiting, unusual tiredness/weakness, severe stomach/abdominal pain, yellowing eyes/skin, dark urine), numbness/tingling of arms/legs, toe/joint pain.
Tell your doctor immediately if any of these rare but serious side effects occur: mental/mood disorders (such as confusion, hallucinations), signs of a new infection (such as fever, persistent sore throat), easy bleeding/bruising.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Myambutol (Ethambutol)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Myambutol FDA Prescribing Information: Side Effects
MYAMBUTOL may produce decreases in visual acuity, including irreversible blindness, which appear to be due to optic neuritis. Optic neuropathy including optic neuritis or retrobulbar neuritis occurring in association with ethambutol therapy may be characterized by one or more of the following events: decreased visual acuity, scotoma, color blindness, and/or visual defect. These events have also been reported in the absence of a diagnosis of optic or retrobulbar neuritis.
Patients should be advised to report promptly to their physician any change of visual acuity.
The change in visual acuity may be unilateral or bilateral and hence each eye must be tested separately and both eyes tested together. Testing of visual acuity should be performed before beginning MYAMBUTOL therapy and periodically during drug administration, except that it should be done monthly when a patient is on a dosage of more than 15 mg per kilogram per day. Snellen eye charts are recommended for testing of visual acuity. Studies have shown that there are definite fluctuations of one or two lines of the Snellen chart in the visual acuity of many tuberculous patients not receiving MYAMBUTOL.
The following table may be useful in interpreting possible changes in visual acuity attributable to MYAMBUTOL.
|Initial Snellen Reading||Reading Indicating Significant Decrease||Significant Number of Lines||Decrease Number of Points|
In general, changes in visual acuity less than those indicated under “Significant Number of Lines” and “Decrease Number of Points” may be due to chance variation, limitations of the testing method, or physiologic variability. Conversely, changes in visual acuity equaling or exceeding those under “Significant Number of Lines” and “Decrease Number of Points” indicate need for retesting and careful evaluation of the patient's visual status. If careful evaluation confirms the magnitude of visual change and fails to reveal another cause, MYAMBUTOL should be discontinued and the patient reevaluated at frequent intervals. Progressive decreases in visual acuity during therapy must be considered to be due to MYAMBUTOL.
If corrective glasses are used prior to treatment, these must be worn during visual acuity testing. During 1 to 2 years of therapy, a refractive error may develop which must be corrected in order to obtain accurate test results. Testing the visual acuity through a pinhole eliminates refractive error. Patients developing visual abnormality during MYAMBUTOL treatment may show subjective visual symptoms before, or simultaneously with, the demonstration of decreases in visual acuity, and all patients receiving MYAMBUTOL should be questioned periodically about blurred vision and other subjective eye symptoms.
Recovery of visual acuity generally occurs over a period of weeks to months after the drug has been discontinued. Some patients have received MYAMBUTOL (ethambutol hydrochloride) again after such recovery without recurrence of loss of visual acuity. Other adverse reactions reported include: hypersensitivity, anaphylactic/anaphylactoid reaction, dermatitis, erythema multiforme, pruritus, and joint pain; anorexia, nausea, vomiting, gastrointestinal upset, and abdominal pain; fever, malaise, headache, and dizziness; mental confusion, disorientation, and possible hallucinations; thrombocytopenia, leukopenia, and neutropenia. Numbness and tingling of the extremities due to peripheral neuritis have been reported. Elevated serum uric acid levels occur and precipitation of acute gout has been reported. Pulmonary infiltrates, with or without eosinophilia, also have been reported during MYAMBUTOL therapy. Liver toxicities, including fatalities, have been reported. (See WARNINGS). Since MYAMBUTOL is recommended for therapy in conjunction with one or more other antituberculous drugs, these changes may be related to the concurrent therapy. Hypersensitivity syndrome consisting of cutaneous reaction (such as rash or exfoliative dermatitis), eosinophilia, and one or more of the following: hepatitis, pneumonitis, nephritis, myocarditis, pericarditis. Fever and lymphadenopathy may be present.
Read the entire FDA prescribing information for Myambutol (Ethambutol)
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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