Mycostatin (Nystatin) Drug Information: Clinical Pharmacology

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May 27, 2012

Mycostatin

Dental Medications »

Introduction to dental medications

There are several types of medications that are used to manage a variety of diseases involving the oral cavity (mouth) that are part of good dental care. The medications discussed in this article have pharmacological properties that are used to treat conditions such as pain, anxiety, and infections, amongst others.

It is important to always communicate all dental signs and symptoms to your dentist, so that appropriate management and choice of medications can be made.

Medications used to control pain and anxiety

One of the most commonly reported dental complications involves various levels of pain. Due to this fact, pain management is an important goal for all dentists and patients.

Analgesics

Non-narcotic analgesics are the most commonly used drugs for relief of toothache or pain following dental treatment as well as fever. The commonly-used med...

Read the Dental Medications article »

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CLINICAL PHARMACOLOGY

Pharmacokinetics

Nystatin is not absorbed from intact skin or mucous membrane.

Microbiology

Nystatin is an antibiotic which is both fungistatic and fungicidalin vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes.

Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Generally, resistance to nystatin does not develop during therapy. However, other species of Candida (C. tropicalis, C. guilliermondi, C. krusei, and C. stellatoides) become quite resistant on treatment with nystatin and simultaneously become cross resistant to amphotericin as well. This resistance is lost when the antibiotic is removed. Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses.

Last reviewed on RxList: 4/8/2009
This monograph has been modified to include the generic and brand name in many instances.