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Myfortic

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Myfortic®
(mycophenolic acid*) Delayed-Release Tablets
*as Mycophenolate Sodium

WARNING

Immunosuppression may lead to increased susceptibility to infection and possible development of lymphoma and other neoplasms. Only physicians experienced in immunosuppressive therapy and management of organ transplant recipients should use Myfortic® (mycophenolic acid). Patients receiving Myfortic (mycophenolic acid) should be managed in facilities equipped and staffed with adequate laboratory and supportive medical resources. The physician responsible for maintenance therapy should have complete information requisite for the follow-up of the patient.

Female users of childbearing potential must use contraception. Use of Myfortic® (mycophenolic acid) during pregnancy is associated with increased risks of pregnancy loss and congenital malformations.

DRUG DESCRIPTION

Myfortic® (mycophenolic acid) delayed-release tablets are an enteric formulation of mycophenolate sodium that delivers the active moiety mycophenolic acid (MPA). Myfortic (mycophenolic acid) is an immunosuppressive agent. As the sodium salt, MPA is chemically designated as (E)-6-(4hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid sodium salt.

Its empirical formula is C17H19O6Na. The molecular weight is 342.32 and the structural formula is

Myfortic® (mycophenolic acid) Structural Formula Illustration

Myfortic (mycophenolic acid) , as the sodium salt, is a white to off-white, crystalline powder and is highly soluble in aqueous media at physiological pH and practically insoluble in 0.1 N hydrochloric acid.

Myfortic (mycophenolic acid) is available for oral use as delayed-release tablets containing either 180 mg or 360 mg of mycophenolic acid. Inactive ingredients include colloidal silicon dioxide, crospovidone, lactose anhydrous, magnesium stearate, povidone (K-30), and starch. The enteric coating of the tablet consists of hypromellose phthalate, titanium dioxide, iron oxide yellow, and indigotine (180 mg) or iron oxide red (360 mg).

What are the possible side effects of mycophenolic acid (Myfortic)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any a serious side effect such as:

  • fever, chills, body aches, flu symptoms, mouth sores, white patches in your mouth or throat;
  • pale skin, easy bruising or bleeding, unusual weakness, trouble breathing, fast heart rate;
  • coughing up blood or vomit that looks like coffee grounds;
  • bloody,...

Read All Potential Side Effects and See Pictures of Myfortic »

What are the precautions when taking mycophenolic acid (Myfortic)?

Before taking mycophenolate sodium, tell your doctor or pharmacist if you are allergic to it; or to mycophenolic acid, or mycophenolate mofetil; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: any type of cancer, liver disease, stomach/intestinal problems (e.g., ulcers), rare genetic disorders (e.g., Lesch-Nyhan or Kelley-Seegmiller syndromes).

If your transplanted kidney does not work properly even though you are taking this medication, the amount of mycophenolate in your body may increase, which can result in increased side...

Read All Potential Precautions of Myfortic »

Last reviewed on RxList: 10/26/2009
This monograph has been modified to include the generic and brand name in many instances.

Myfortic - User Reviews

Myfortic User Reviews

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